Regulation of synthesis of immunoglobulins

  • T. A. Waldmann
  • S. Broder
  • M. Durm
  • M. Blackman


Turnover studies using radioiodinated purified immunoglobulin molecules have been used to define the metabolic parameters of the different classes of immunoglobulins in normal man and to define the physiological factors regulating immunoglobulin catabolism and transport1. In addition, as we have emphasised in previous Congresses, such studies have lead to the development of new insights into the pathophysiology of abnormalities of immunoglobulin levels and have led to the discovery of new classes of immunodeficiency disease associated with short survivals of immunoglobulin molecules2. Such turnover studies, however, are not of major value in the definition of the complex pathways of cellular differentiation and biosynthesis which are required for the normal immune response and for immunoglobulin biosynthesis, nor are they of value in defining the precise defects in these events that occur in patients with the different immunodeficiency diseases. We have, therefore, developed an entirely different technique to study the factors controlling immunoglobulin synthesis and secretion by lymphocytes and their daughter cells. These studies have been directed towards defining the physiological control mechanisms that regulate immunoglobulin synthesis and toward developing new insights into the nature of the defects of immunoglobulin synthesis and secretion that occur in patients with the primary immunodeficiency diseases or with the neoplastic diseases affecting lymphocytes and plasma cells.


Chronic Lymphocytic Leukemia Peripheral Blood Lymphocyte Normal Lymphocyte Common Variable Immunodeficiency Primary Immunodeficiency Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Waldmann, T. A. and Strober, W. Progr. Allergy. 13 (1969), 1–110Google Scholar
  2. 2.
    Strober, W., Blaese, R. M. and Waldmann, T. A. (1970) In Plasma Protein Metabolism, Rothschild, M. A. and Waldmann, T., eds., Academic Press, New York, pp. 287–305Google Scholar
  3. 3.
    Gershon, R. K. (1974) In Contemporary Topics in Immunobiology, Cooper, M. D. and Warner, N. L., eds. Volume 3, pp. 1–40CrossRefGoogle Scholar
  4. 4.
    Grey, H. M., Rabellino, E. and Pirofsky, B. J. Clin. Invest., 50 (1971), 2368–2375CrossRefGoogle Scholar
  5. 5.
    Preud’homme, J. L. and Seligmann, M. Lancet, 1 (1972), 442CrossRefGoogle Scholar
  6. 6.
    Gajl-Peczalska, K. J., Park, B. H., Biggar, W. D. and Good, R. A. J. Clin. Invest., 52 (1973), 919–928CrossRefGoogle Scholar
  7. 7.
    Cooper, M. D., Lawton, A. R. and Bockman, D. E. Lancet, 2 (1971), 791–795CrossRefGoogle Scholar
  8. 8.
    Lawton, A. R., Royal, S. A., Self, K. S. and Cooper, M. D. J. Lab. Clin. Med., 80 (1972), 26–33Google Scholar
  9. 9.
    Waldmann, T. A., Polmar, S. H., Balestra, S. T., Jost, M. C., Bruce, R. M. and Terry, W. D. J. Immunol., 109 (1972), 304–310Google Scholar
  10. 10.
    Wybran, J., Chantier, S. and Fudenberg, H. H. Lancet, 1 (1973), 126–129CrossRefGoogle Scholar
  11. 11.
    Yam, L. T., Li, C. Y. and Crosby, W. H. Amer. J. Clin. Path., 55 (1971), 283–290Google Scholar
  12. 1.
    Geha, R. S., Schneeberger, E., Merler, E. and Rosen, F. S. Heterogeneity of ‘acquired’ or common variable agammaglobulinemia. New Engl. J. Med., 291 (1974), 1CrossRefGoogle Scholar
  13. 2.
    Sherr, C. J. and Uhr, J. W. Immunoglobulin synthesis and secretion. VI. Synthesis and intracellular transport of immunoglobulin in nonsecretory lymphoma cells. J. Exp. Med., 133 (1971), 901CrossRefGoogle Scholar

Copyright information

© The Contributors 1976

Authors and Affiliations

  • T. A. Waldmann
  • S. Broder
  • M. Durm
  • M. Blackman

There are no affiliations available

Personalised recommendations