Advertisement

Albumin depletion in uremic patients on conservative management

  • R. Bianchi
  • G. Mariani
  • A. Pilo
  • M. G. Toni
  • F. Carmassi

Abstract

The purpose of this work was to investigate how a long-term low protein diet could affect albumin metabolism of patients with chronic uremia, on the assumption that this protein reflects to some extent the behaviour of the whole body proteins1–3. In fact, prolonged low protein diet in these patients as the only type of conservative management, raises the problem as to whether a dangerous protein malnutrition could ensue4.

Keywords

Uremic Patient Serum Albumin Concentration Albumin Synthesis Protein Depletion Chronic Uremia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Shemin, D., Rittenberg, D. Some interrelationships in general nitrogen metabolism. J. Biol. Chem., 153 (1944), 401–421Google Scholar
  2. 2.
    Solomon, G., Tarver, H. The effect of diet on the rate of loss of labelled amino acids from tissue proteins. J. Biol. Chem., 195 (1952), 447–452Google Scholar
  3. 3.
    Carrow, J. S. The effect of protein depletion on the distribution of protein synthesis in the dog. J. Clin. Invest., 38 (1952), 1241–1250Google Scholar
  4. 4.
    Wang, F. Conservative management of chronic renal failure. In Med. Clin. North Am., 55 (1971), 137–154Google Scholar
  5. 5.
    Giovannetti, S., Maggiore, Q. A low nitrogen diet with proteins of high biological value for severe chronic uremia. Lancet, 1 (1964), 1000–1003CrossRefGoogle Scholar
  6. 6.
    Rosa, U., Pennisi, F., Bianchi, R., Federighi, G., Donato, L. Chemical and biological effects of iodination on human albumin. Biochim. Biophys. Acta 133 (1967), 486–498CrossRefGoogle Scholar
  7. 7.
    Bianchi, R., Mariani, G. An improved biochemical method for the determination of synthesis rate of liver produced plasma proteins by 14C-carbonate. J. Nucl. Biol. Med., 13 (1969), 167–171Google Scholar
  8. 8.
    Donato, L., Vitek, F., Bianchi, R., Federighi, G. A double tracer method for metabolic studies with iodinated proteins or polypeptides in presence of a relatively slow excretion of iodide. J. Nucl. Biol. Med., 11 (1967), 1–8Google Scholar
  9. 9.
    Bianchi, R., Donato, L., Mancini, P., Mariani, G. Pilo, A. and Vitek, F. (1970) Models for protein synthesis studies. In Plasma Protein Metabolism, M. A. Rothschild and T. A. Waldmann, eds., Academic Press, New York, pp. 25–49Google Scholar
  10. 10.
    Bianchi, R., Mariani, G. and Pilo, A. Albumin synthesis measurement by means of an improved two tracer method in patients with chronic renal failure. Effects of low protein diet. J. Nucl. Biol. Med., 14 (1970), 136–144Google Scholar
  11. 11.
    Bianchi, R., Mariani, G. and Pilo, A. (1972) Albumin metabolism in uremic patients on low protein diet. In Uremia, R. Kluthe, G. M. Berlyne and B. T. Burton, eds., Georg Thieme Verlag, Stuttgart, 206–219Google Scholar
  12. 12.
    Bianchi, R., Mariani, G. and Pilo, A. Short-term measurement of plasma protein catabolism in man. In Radioaktive Isotope in Klinik and Forschung, 10th ed., K. Fellinger and R. Höfer, eds., Urban and Scharzenberg, München, pp. 94–101Google Scholar
  13. 13.
    Bianchi, R., Mariani, G., Pilo, A. and Toni, M. G. Short-term determination of serum albumin catabolism in man from plasma data only J. Nucl. Biol. Med., 17 (1973), 117–118Google Scholar
  14. 14.
    Bianchi, R., Mariani, G., Pilo, A., Toni, M. G. and Donato, L. (1973) Short-term determination of plasma protein turnover by a two-tracer technique using plasma only or plasma and urine data. In Protein Turnover ASP, Amsterdam, pp. 47–72Google Scholar
  15. 15.
    Jones, E. A., Craigie, A., Tavill, A. S., Simon, W. and Rosenoer, V. M. Urea kinetics and the direct measurement of the synthetic rate of albumin utilising 14C-carbonate. Clin. Sci., 35 (1968), 553–564Google Scholar
  16. 16.
    Pearson, J. D., Veall, N. and Vetter, H. A practical method for plasma albumin turnover studies. Strahlentherapie, 38 (1956), 290Google Scholar
  17. 17.
    Bianchi, R., Mariani, G., Pilo, A. and Donato, L. (1972) Albumin metabolism in patients with chronic renal failure on low protein balanced diet. In Protides of the Biological Fluids, 19th ed., H. Peeters, ed., Pergamon Press, Oxford, pp. 483–487CrossRefGoogle Scholar
  18. 18.
    Bianchi, R., Federighi, G., Giagnoni, P., Giordani, R., Navalesi, R. and Donato, L. (1968) Patterns of serum albumin metabolism in renal diseases. In Physiology and Pathophysiology of Plasma Protein Metabolism, G. Birke, R. Norberg and L. O. Plantin, eds., Pergamon Press, Oxford, pp. 195–211Google Scholar
  19. 19.
    Picou, D. and Waterlow, J. C. The effect of malnutrition on the metabolism of plasma albumin. Clin. Sci., 22 (1962), 459–468Google Scholar
  20. 20.
    Hoffenberg, R., Black, E. and Brock, J. F. Albumin and gamma globulin tracer studies in protein depletion states. J. Clin. Invest., 45 (1966), 143–152CrossRefGoogle Scholar
  21. 21.
    Whitehead, R. G., Frood, J. D. L. and Poskitt, E. M. E. Value of serum albumin measurements in nutritional surveys. A reappraisal. Lancet, 2 (1971), 287–289CrossRefGoogle Scholar
  22. 22.
    Cohen, S. and Hansen, J. D. L. Metabolism of albumin and gammaglobulin in kwashiorkor. Clin. Sci., 23 (1962), 351–359Google Scholar
  23. 23.
    James, W. P. T. and Hay, A. M. Albumin metabolism. Effect of the nutritional state and the dietary protein intake. J. Clin. Invest., 47 (1968), 1958–1972CrossRefGoogle Scholar
  24. 24.
    Kirsch, R., Frith, L., Black, E. and Hoffenberg, R. Regulation of albumin synthesis and catabolism by alteration of dietary protein. Nature, 217 (1968), 578–579CrossRefGoogle Scholar
  25. 25.
    Bianchi, R., Mariani, G., Pilo, A. and Toni, M. G. Serum albumin turnover in liver cirrhosis. J. Nucl. Biol. Med., 18 (1974), 20–29Google Scholar
  26. 26.
    Mariani, G., Bianchi, R., Pilo, A., Palla, R., Toni, M. G. and Fusani, L. Albumin catabolism measurement by a two tracer technique in uremic patients during a single dialytic treatment. Europe. J. Clin. Invest., 1974 4 (1974), 435Google Scholar
  27. 1.
    Guyton, A. personal communicationGoogle Scholar
  28. 2.
    Giordano, C. Use of exogenous and endogenous urea for protein synthesis in normal and uremic subjects. J. Lab. Clin. Med., 62 (1963), 231Google Scholar
  29. 3.
    Richards, P. Protein metabolism in uremia. Nephron, 14 (1975), 135CrossRefGoogle Scholar
  30. 4.
    Varcoe, R., Halliday, D., Carson, E. R., Richards, P. and Tavill, A. S. (1975) Efficiency of utilization of urea nitrogen for albumin synthesis by chronically uraemic and normal man. Clin. Sci. and Mol. Med., In press.Google Scholar

Copyright information

© The Contributors 1976

Authors and Affiliations

  • R. Bianchi
  • G. Mariani
  • A. Pilo
  • M. G. Toni
  • F. Carmassi

There are no affiliations available

Personalised recommendations