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Protein synthesis in the perfused liver: Comparative evaluation of the influence of amino acid supply on ribosomal activity of intact and isolated perfused rat liver

  • Chapter
Plasma Protein Turnover

Abstract

Many investigators1,2 have demonstrated that starvation or dietary protein deprivation produces an immediate fall in synthesis of albumin which returns promptly to normal or above normal levels within 24 hours of refeeding an adequate diet, and there are suggestions that the changes in albumin synthetic rate are mediated by the availability of amino acids to the hepatic cells1. Such observations have triggered widespread interest in the effects of amino acid supply on the cellular organelles involved in protein biosynthesis. Hepatic cytoplasmic ribosomes, as in most mammalian cells, exist either as free ribosomes or bound to membranes of the rough endoplasmic reticulum3.

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Authors
  1. C. O. Enwonwu
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Editor information

Editors and Affiliations

  1. Second Medical Clinic and C.N.R. Clinical Physiology Laboratory, University of Pisa, Italy

    R. Bianchi  & G. Mariani  & 

  2. Clinical Research Centre, Harrow, Middlesex, UK

    A. S. McFarlane

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© 1976 The Contributors

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Enwonwu, C.O. (1976). Protein synthesis in the perfused liver: Comparative evaluation of the influence of amino acid supply on ribosomal activity of intact and isolated perfused rat liver. In: Bianchi, R., Mariani, G., McFarlane, A.S. (eds) Plasma Protein Turnover. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-02644-9_17

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