Abstract
In recent years, Ashwell, Morell, Scheinberg and their colleagues established a hepatic pathway for the elimination of a number of desialylated glycoproteins (e.g. the asialo derivatives of ceruloplasmin, orosomucoid, haptoglobin, fetuin, α2-macroglobulin and thyroglobulin) from the circulation. In essence desialylation is effective through the exposure of penterminal galactosyl groups which mediate the binding of the.modified protein to a glycoprotein on the plasma membrane of hepatocytes. In addition to the paper given by Scheinberg (p. 121), several excellent review articlesl1,2 are available as a source of detailed information regarding the hepatic clearance mechanism for asialoglycoproteins.
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References
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Regoeczi, E., Hatton, M.W.C. (1976). In vivo behaviour of asialotransferrins. In: Bianchi, R., Mariani, G., McFarlane, A.S. (eds) Plasma Protein Turnover. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-02644-9_12
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DOI: https://doi.org/10.1007/978-1-349-02644-9_12
Publisher Name: Palgrave Macmillan, London
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