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Life and death of plasma proteins

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Abstract

The work that I shall report on today has occupied much of the effort in our laboratory for the past six or seven years. It has represented a collaborative effort of Anatol Morell, Irmin Sternlieb, Richard Stockert, C. J. A. van den Hamer, Gregory Gregoriadis, all working in my laboratory, and Gilbert Ashwell and his collaborators in Bethesda1– 10.

The research reported in this chapter was supported, in part, by grant AM 1059, National Institute of Arthritis, Metabolism and Digestive Diseases of the U.S. Department of Health, Education and Welfare and by the Foundation for the Study of Wilson’s Disease, Inc.

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References

  1. Morell, A. G., Van Den Hamer, C. J. A., Scheinberg, I. H. and Ashwell, G. Physical and chemical studies on ceruloplasmin. IV. Preparation of radioactive, sialic acid-free ceruloplasmin, labelled with tritium on terminal D-galactose residues. J. Biol. Chem., 241 (1966), 3745–3749

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  2. Morell, A. G., Irvine, R. A., Sternlieb, I., Scheinberg, I. H. and Ashwell, G. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J. Biol. Chem., 243 (1968), 155–159

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  3. Morell, A. G., Sternlieb, I. and Scheinberg, I. H. Physical and chemical studies on ceruloplasmin: Crystallisation of desialised human ceruloplasmin asialoceruloplasmin. Science, 166 (1969), 1293–1294

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  4. Hickman, J., Ashwell, G., Morell, A. G., Van Den Hamer, C. J. A. and Scheinberg, I. H. Physical and chemical studies on ceruloplasmin. VIII. Preparation of N-acetylneuraminic acid-1–14C-labelled ceruloplasmin. J. Biol. Chem., 245 (1970), 759–766

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  5. Van Den Hamer, C. J. A., Morell, A. G., Scheinberg, I. H., Hickman, J. and Ashwell, G. Physical and chemical studies on ceruloplasmin. IX. The role of galactosyl residues in the clearance of ceruloplasmin from the circulation. J. Biol. Chem., 245 (1970), 4397–4402

    Google Scholar 

  6. Gregoriadis, G., Morell, A. G., Sternlieb, I. and Scheinberg, I. H. Catabolism of desialylated ceruloplasmin in the liver. J. Biol. Chem., 245 (1970), 5833–5837

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  7. Morell, A. G., Gregoriadis, G., Scheinberg, I. H., Hickman, J. and Ashwell, G. The role of sialic acid in determining the survival of glycoproteins in the circulation. J. Biol. Chem., 246 (1971), 1461–1467

    Google Scholar 

  8. Morell, A. G. and Scheinberg, I. H. Solubilisation of hepatic binding sites for asialo-glycoproteins. Biochem. Biophys. Res. Comm., 48 (1972), 808–815

    Article  Google Scholar 

  9. Sternlieb, I., Morell, A. G. and Scheinberg, I. H. The remarkable selectivity of hepatocytes in the uptake of glycoproteins. Gastroenterology, 64 (1973), 1049–1052

    Google Scholar 

  10. Stockert, R. J., Morell, A. G. and Scheinberg, I. H. Mammalian hepatic lectin. Science, 186 (1974), 365–366

    Article  Google Scholar 

  11. Benacerraf, B. (1958) Quantitative aspects of phagocytosis. Proceedings of the Symposium on Liver Function, Brauer, R. W., ed., American Institute of Biological Sciences, Washington, pp. 205–227

    Google Scholar 

  12. Regoeczi, E. and Hatton, M. W. C. Studies of the metabolism of asialotransferrins: The mechanism for the hypercatabolism of human asialotransferrin in the rabbit. Canad. J. Biochem., 52 (1974), 645–651

    Article  Google Scholar 

  13. Cohen, G. L., Mannik, M. Catabolism of gamma-6-globulin with reduced interchain disulphide bonds in rabbits. J. Immunol., 96 (1966), 683

    Google Scholar 

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Scheinberg, I.H. (1976). Life and death of plasma proteins. In: Bianchi, R., Mariani, G., McFarlane, A.S. (eds) Plasma Protein Turnover. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-02644-9_11

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