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Life and death of plasma proteins

  • I. H. Scheinberg

Abstract

The work that I shall report on today has occupied much of the effort in our laboratory for the past six or seven years. It has represented a collaborative effort of Anatol Morell, Irmin Sternlieb, Richard Stockert, C. J. A. van den Hamer, Gregory Gregoriadis, all working in my laboratory, and Gilbert Ashwell and his collaborators in Bethesda1– 10.

Keywords

Sialic Acid Sialic Acid Residue Galactose Residue Galactose Oxidase Plasma Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Morell, A. G., Van Den Hamer, C. J. A., Scheinberg, I. H. and Ashwell, G. Physical and chemical studies on ceruloplasmin. IV. Preparation of radioactive, sialic acid-free ceruloplasmin, labelled with tritium on terminal D-galactose residues. J. Biol. Chem., 241 (1966), 3745–3749Google Scholar
  2. 2.
    Morell, A. G., Irvine, R. A., Sternlieb, I., Scheinberg, I. H. and Ashwell, G. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J. Biol. Chem., 243 (1968), 155–159Google Scholar
  3. 3.
    Morell, A. G., Sternlieb, I. and Scheinberg, I. H. Physical and chemical studies on ceruloplasmin: Crystallisation of desialised human ceruloplasmin asialoceruloplasmin. Science, 166 (1969), 1293–1294CrossRefGoogle Scholar
  4. 4.
    Hickman, J., Ashwell, G., Morell, A. G., Van Den Hamer, C. J. A. and Scheinberg, I. H. Physical and chemical studies on ceruloplasmin. VIII. Preparation of N-acetylneuraminic acid-1–14C-labelled ceruloplasmin. J. Biol. Chem., 245 (1970), 759–766Google Scholar
  5. 5.
    Van Den Hamer, C. J. A., Morell, A. G., Scheinberg, I. H., Hickman, J. and Ashwell, G. Physical and chemical studies on ceruloplasmin. IX. The role of galactosyl residues in the clearance of ceruloplasmin from the circulation. J. Biol. Chem., 245 (1970), 4397–4402Google Scholar
  6. 6.
    Gregoriadis, G., Morell, A. G., Sternlieb, I. and Scheinberg, I. H. Catabolism of desialylated ceruloplasmin in the liver. J. Biol. Chem., 245 (1970), 5833–5837Google Scholar
  7. 7.
    Morell, A. G., Gregoriadis, G., Scheinberg, I. H., Hickman, J. and Ashwell, G. The role of sialic acid in determining the survival of glycoproteins in the circulation. J. Biol. Chem., 246 (1971), 1461–1467Google Scholar
  8. 8.
    Morell, A. G. and Scheinberg, I. H. Solubilisation of hepatic binding sites for asialo-glycoproteins. Biochem. Biophys. Res. Comm., 48 (1972), 808–815CrossRefGoogle Scholar
  9. 9.
    Sternlieb, I., Morell, A. G. and Scheinberg, I. H. The remarkable selectivity of hepatocytes in the uptake of glycoproteins. Gastroenterology, 64 (1973), 1049–1052Google Scholar
  10. 10.
    Stockert, R. J., Morell, A. G. and Scheinberg, I. H. Mammalian hepatic lectin. Science, 186 (1974), 365–366CrossRefGoogle Scholar
  11. 11.
    Benacerraf, B. (1958) Quantitative aspects of phagocytosis. Proceedings of the Symposium on Liver Function, Brauer, R. W., ed., American Institute of Biological Sciences, Washington, pp. 205–227Google Scholar
  12. 12.
    Regoeczi, E. and Hatton, M. W. C. Studies of the metabolism of asialotransferrins: The mechanism for the hypercatabolism of human asialotransferrin in the rabbit. Canad. J. Biochem., 52 (1974), 645–651CrossRefGoogle Scholar
  13. 1.
    Cohen, G. L., Mannik, M. Catabolism of gamma-6-globulin with reduced interchain disulphide bonds in rabbits. J. Immunol., 96 (1966), 683Google Scholar

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© The Contributors 1976

Authors and Affiliations

  • I. H. Scheinberg

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