Abstract
The work that I shall report on today has occupied much of the effort in our laboratory for the past six or seven years. It has represented a collaborative effort of Anatol Morell, Irmin Sternlieb, Richard Stockert, C. J. A. van den Hamer, Gregory Gregoriadis, all working in my laboratory, and Gilbert Ashwell and his collaborators in Bethesda1– 10.
The research reported in this chapter was supported, in part, by grant AM 1059, National Institute of Arthritis, Metabolism and Digestive Diseases of the U.S. Department of Health, Education and Welfare and by the Foundation for the Study of Wilson’s Disease, Inc.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Morell, A. G., Van Den Hamer, C. J. A., Scheinberg, I. H. and Ashwell, G. Physical and chemical studies on ceruloplasmin. IV. Preparation of radioactive, sialic acid-free ceruloplasmin, labelled with tritium on terminal D-galactose residues. J. Biol. Chem., 241 (1966), 3745–3749
Morell, A. G., Irvine, R. A., Sternlieb, I., Scheinberg, I. H. and Ashwell, G. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. J. Biol. Chem., 243 (1968), 155–159
Morell, A. G., Sternlieb, I. and Scheinberg, I. H. Physical and chemical studies on ceruloplasmin: Crystallisation of desialised human ceruloplasmin asialoceruloplasmin. Science, 166 (1969), 1293–1294
Hickman, J., Ashwell, G., Morell, A. G., Van Den Hamer, C. J. A. and Scheinberg, I. H. Physical and chemical studies on ceruloplasmin. VIII. Preparation of N-acetylneuraminic acid-1–14C-labelled ceruloplasmin. J. Biol. Chem., 245 (1970), 759–766
Van Den Hamer, C. J. A., Morell, A. G., Scheinberg, I. H., Hickman, J. and Ashwell, G. Physical and chemical studies on ceruloplasmin. IX. The role of galactosyl residues in the clearance of ceruloplasmin from the circulation. J. Biol. Chem., 245 (1970), 4397–4402
Gregoriadis, G., Morell, A. G., Sternlieb, I. and Scheinberg, I. H. Catabolism of desialylated ceruloplasmin in the liver. J. Biol. Chem., 245 (1970), 5833–5837
Morell, A. G., Gregoriadis, G., Scheinberg, I. H., Hickman, J. and Ashwell, G. The role of sialic acid in determining the survival of glycoproteins in the circulation. J. Biol. Chem., 246 (1971), 1461–1467
Morell, A. G. and Scheinberg, I. H. Solubilisation of hepatic binding sites for asialo-glycoproteins. Biochem. Biophys. Res. Comm., 48 (1972), 808–815
Sternlieb, I., Morell, A. G. and Scheinberg, I. H. The remarkable selectivity of hepatocytes in the uptake of glycoproteins. Gastroenterology, 64 (1973), 1049–1052
Stockert, R. J., Morell, A. G. and Scheinberg, I. H. Mammalian hepatic lectin. Science, 186 (1974), 365–366
Benacerraf, B. (1958) Quantitative aspects of phagocytosis. Proceedings of the Symposium on Liver Function, Brauer, R. W., ed., American Institute of Biological Sciences, Washington, pp. 205–227
Regoeczi, E. and Hatton, M. W. C. Studies of the metabolism of asialotransferrins: The mechanism for the hypercatabolism of human asialotransferrin in the rabbit. Canad. J. Biochem., 52 (1974), 645–651
Cohen, G. L., Mannik, M. Catabolism of gamma-6-globulin with reduced interchain disulphide bonds in rabbits. J. Immunol., 96 (1966), 683
Editor information
Editors and Affiliations
Copyright information
© 1976 The Contributors
About this chapter
Cite this chapter
Scheinberg, I.H. (1976). Life and death of plasma proteins. In: Bianchi, R., Mariani, G., McFarlane, A.S. (eds) Plasma Protein Turnover. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-02644-9_11
Download citation
DOI: https://doi.org/10.1007/978-1-349-02644-9_11
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-02646-3
Online ISBN: 978-1-349-02644-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)