Protein turnover studies in the assessment of liver function

  • V. M. Rosenoer


The characteristic electrophoretic pattern of the plasma proteins in cirrhosis of the liver, with the low concentration of serum albumin and raised concentration of globulins, has long suggested that the serum albumin concentration and the ratio of the concentrations of albumin to globulin could be considered as quantitative indices of liver function. Indeed, Post and Patek1 were able to relate the serum albumin level to prognosis in patients without ascites.


Primary Biliary Cirrhosis Synthesis Rate Albumin Concentration Active Chronic Hepatitis Serum Albumin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Post, J. and Patek, A. S. Serum proteins in cirrhosis of the liver. Arch. Intern. Med., 69 (1942), 67–82 and 83–89CrossRefGoogle Scholar
  2. 2.
    Schultze, H. E. and Heremans, J. F. (1966) Molecular Biology of Human Proteins. Vol. I. Nature and Metabolism of Extracellular Proteins. Elsevier, New YorkGoogle Scholar
  3. 3.
    Feizi, T. Immunoglobulins in chronic liver disease. Gut, 9 (1968), 193–198CrossRefGoogle Scholar
  4. 4.
    Alper, C. A., Peters, J. H., Birtch, A. G. and Gardner, F. H. Haptoglobin synthesis. I. In vivo studies of the production of haptoglobin, fibrinogen and y-globulin by the canine liver. J. Clin. Invest., 44 (1965), 574–581CrossRefGoogle Scholar
  5. 5.
    Tavill, A. S., Craigie, A. and Rosenoer, V. M. The measurement of the synthetic rate of albumin in man. Clin. Sci., 34 (1968), 1–28Google Scholar
  6. 6.
    Hällén, J. and Laurell, C. B. Plasma protein pattern in cirrhosis of the liver. Scand. J. Clin. Lab. Invest., 29 (Supplement 142) (1972), 97–103Google Scholar
  7. 7.
    Rothschild, M. A., Oratz, M., Zimmon, D., Schreiber, S. S., Weiner, I. and Van Caneghem, A. Albumin synthesis in cirrhotic subjects with ascites studied with carbonate 14C. J. Clin. Invest., 48 (1969), 344–350CrossRefGoogle Scholar
  8. 8.
    Hasch, E., Jarnum, S. and Tygstrup, N. Albumin synthesis rate as a measure of liver function in patients with cirrhosis. Acta Med. Scand., 182 (1967), 83–92CrossRefGoogle Scholar
  9. 9.
    Rothschild, M. A., Oratz, M. and Schreiber, S. S. Alcohol, amino acids and albumin synthesis. Gastroenterology, 67 (1974), 1200–1213Google Scholar
  10. 10.
    Jones, E. A., Craigie, A., Tavill, A. S., Franglen, G. and Rosenoer, V. M. Albumin and urea synthesis in the ‘blind loop’ syndrome. Gut, 9 (1968), 466–469CrossRefGoogle Scholar
  11. 11.
    Rothschild, M. A., Bauman, A., Yalow, R. S. and Berson, S. A. The effect of large doses of dessicated thyroid on the distribution and metabol- ism of albumin 131I in euthyroid subjects. J. Clin. Invest., 36 (1957), 422CrossRefGoogle Scholar
  12. 12.
    Lewallen C. G., Rall, J. E. and Berman, M. Studies on iodoalbumin metabolism. II. The effects of thyroid hormone. J. Clin. Invest., 38 (1959), 88CrossRefGoogle Scholar
  13. 13.
    Bauman, A., Rothschild, M. A., Yalow, R. S. and Berson, S. A. Distribution and metabolism of 131I labelled human serum albumin in congestive heart failure with and without proteinuria. J. Clin. Invest., 34 (1957), 1359CrossRefGoogle Scholar
  14. 14.
    Rothschild, M. A., Schreiber, S. S., Oratz, M. and McGee, H. L. The effect of adrenocortical hormones on albumin metabolism studied with 131I albumin. J. Clin. Invest., 37 (1958), 1229CrossRefGoogle Scholar
  15. 15.
    Cain, G. D., Mayer, G. and Jones, E. A. Augmentation of albumin but not fibrinogen synthesis by corticosteroids in patients with hepatocellular disease. J. Clin. Invest., 49 (1970), 2198–2204CrossRefGoogle Scholar
  16. 16.
    Bianchi, R., Mariani, G., Pilo, A. and Toni, M. G. Serum albumin turnover in liver cirrhosis. J. Nuclear Biol. Med., 18 (1974), 20–29Google Scholar

Copyright information

© The Contributors 1976

Authors and Affiliations

  • V. M. Rosenoer

There are no affiliations available

Personalised recommendations