Some Factors Affecting Skin and Wound Healing

  • George D. Winter
Part of the Strathclyde Bioengineering Seminars book series (BCSDA)


The domestic pig is the preferred animal for studying the effects of environmental factors on skin and wound because its integument is more like that of man than any other. The three factors that most drastically affect the pattern, speed and quality of healing are dehydration of exposed tissues, the status of the blood supply bringing oxygen and nutrients to the area and sepsis.

Wounds exposed to the air lose water vapour, the upper dermis dries and healing takes place beneath a dry scab. Covering a wound with an occlusive dressing prevents scab formation and radically alters the pattern of epidermal wound healing. Blowing on wounds creates a scab within three hours instead of the normal 24. hours but more tissue is sacrificed in the process. This may only be justified if it can be shown that rapid artificial scab formation significantly cuts down the incidence of severe infections, i.e. in large burns. Less serious wounds heal faster when covered with a suitable occlusive dressing.

Indolent wounds are characterised by a rim of infected, necrotic tissue in which leucocytes and macrophages are unable to function effectively through lack of oxygen. A suitable dressing changed frequently can bring about mild debridement and re-establish the conditions for healing.


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  1. Billingham, R. E. and Medawar, P. B. (1955). Contracture and intussusceptive growth in the healing of extensive wounds in mammalian skin. J. Anat., Lond., 89, 114–23.PubMedCentralPubMedGoogle Scholar
  2. Bothwell, J. W. and Rovee, D. T. (1991). The effects of dressings on the repair of cutaneous wounds in humans. In Surgical Dressings and Wound Healing, pp. 78–97 (ed. K.J. Harkiss ). Bradford University Press.Google Scholar
  3. Hinman, C. D., Maibach, H. I. and Winter, G. D. (1963). Effect of air exposure and occlusion on experimental human skin wounds. Nature, Lond., 200, 377–79CrossRefGoogle Scholar
  4. Hunt, T. K. and Zederfeldt, M. D. (1969). Nutritional and environmental aspects of wound healing. In Repair and Regeneration, pp. 217–28 (eds J. E. Dunphy and H. W. Van Winkle ). New York; McGraw-HillGoogle Scholar
  5. Ingram, D. L. (1964). The effect of environmental temperature on heat loss and thermal insulation in the young pig. Res. vet. Sci., 5, 357–64.Google Scholar
  6. Kamp, H. F. and Watts, J. C. (1967). Progressive debridement with control of insensible water loss in burns using a colloidalsilicate dressing. A clinical observation. S. Afr. med.J., 41,651–55Google Scholar
  7. Niinikoski, J. and Kivisaari, J. (1973). Oxygen and wound healing. In Biology of Fibroblast, pp. 591–99 (eds E. Kulonen and J. Pikkarainen ). London; Academic PressGoogle Scholar
  8. Rovee, D. T. and Miller, C. A. (1968). Epidermal role in the breaking strength of wounds. Archs. Surg., g6, 43–52CrossRefGoogle Scholar
  9. Scales, J. T. and Winter, G. D. (1964). `Levitation’. A Possible Means of Treating Burns, pp. 1–1o, Paris; La Cicatrisation Editions du Centre National de la Recherche ScientifiqueGoogle Scholar
  10. Silver, I. A. (1972). Oxygen tension and epithelization. In Epidermal Wound Healing, pp. 291–305 (eds H. I. Maibach and D. T. Royce ). Chicago; Year Book Medical PublishersGoogle Scholar
  11. Simpson, B.J. and Winter, G. D. (1971). A method of studying the performance f dressings using a standard wound in the domestic pig. In Surgical Dressings and Wound Healing, pp. 7o-77 (ed. K. J. Harkiss ). Bradford University PressGoogle Scholar
  12. Tregear, R. T. (1966). Physical Functions of Skin. London; Academic PressGoogle Scholar
  13. Winter, G. D. (1962). Formation of the scab and the rate of epithelisation of superficial wounds in the skin of the young domestic pig. Nature, Lond., 198, 293–94CrossRefGoogle Scholar
  14. Winter, G. D. (1964). Movement of epidermal cells over the wound surface. In Advances in Biology of Skin. 5, Wound Healing, pp. 113–27 (eds W. Montagna and R. E. Billingham ). Oxford; Pergamon PressGoogle Scholar
  15. Winter G. D. (1971). Healing of skin wounds and the influence of dressings on the repair process. In Surgical Dressings and Wound Healing, pp. 46–6o (ed. K.J. Harkiss ). Bradford University PressGoogle Scholar
  16. Winter, G. D. (1972). Epidermal regeneration studied in the domestic pig. In Epidermal Wound Healing, pp. 71–112 (eds H. I. Maiback and D. T. Rovee ). Chicago; Year Book Medical PublishersGoogle Scholar
  17. Winter, G. D. and Clarke, D. W. (1971). The pig as a laboratory animal for the study of wound healing and surgical dressings. In Surgical Dressings and Wound Healing, pp. 61–69 (ed. K. J. Harkiss ). Bradford University PressGoogle Scholar
  18. Winter, G. D. and Perrins, D. J. (1970). Effects of hyperbaric oxygen treatment on epidermal regeneration. In Proceedings of the 4th Internation Congress on Hyperbaric Medicine, pp. 363–68 (eds J. Wada and T. Iwa ). Tokyo; Igaku ShoinGoogle Scholar
  19. Winter, G. D. and Scales, J. T. (1963). Effect of air drying and dressings on the surface of a wound. Nature, Lond., 197, 91–92CrossRefGoogle Scholar

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© Bioengineering Unit, University of Strathclyde 1976

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  • George D. Winter

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