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Recent Trends in Biocompatible Materials and Microcapsular Absorbents for Kidney Function Replacement

  • T. M. S. Chang

Abstract

Semipermeable microcapsules for kidney function replacement (Chang, 1964, 1966, 1969, 1972; Chang et al., 1966) are semipermeable ultrathin polymer membrane envelopes each enclosing an aqueous interior or coating a solid particle. Direct coating is more convenient for use in haemoperfusion, since this results in rigid particles which give less resistance to flow and, in addition, the rigid particles themselves offer a rigid support for the ultrathin membrane.

Keywords

Activate Charcoal Biocompatible Material Rigid Particle Artificial Cell Medium Molecular Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andrade, J. D.,Kunttomo, K., VanWagenen, V., Kastigir, B.,Gough, D., and Kolff, W. J. 1971: Coated adsorbents for direct blood perfusion: HEMA/activated carbon. Trans. Amer. Soc. Artif. Int. Organs 17: 222.Google Scholar
  2. Bokros, J. C., Gott, V. L., Lagrange, L. D., Fadall, A. M., Vos, K. D., and Ramos, M. D. 1969: Correlations between blood compatibility and heparin absorptivity for an impermeable isotropic pyrolytic carbon. J. Biomed. Mat. Res. 3: 497.CrossRefGoogle Scholar
  3. Boretos, J. W., and Pierce, W. S. 1967: Segmented polyurethane: a new elastomer for biomedical applications. Science 158: 1481.CrossRefGoogle Scholar
  4. Chang, T. M. S. 1964: Semipermeable aqueous microcapsules. Science 146: 524.CrossRefGoogle Scholar
  5. Chang, T. M. S. 1966: Semipermeable aqueous microcapsules (‘artificial cells’) with emphasis on experiments in an extracorporeal shunt system. Trans. Amer. Soc. Artif. Int. Organs 12: 13.Google Scholar
  6. Chang, T. M. S. 1969: Removal of endogenous and exogenous toxins by a microencapsulated absorbent. Canad. J. Physiol. Pharmacol. 47: 1043.CrossRefGoogle Scholar
  7. Chang, T. M. S. 1972: ‘Artificial Cells’. Monograph. Charles C. Thomas, Springfield, Ill.Google Scholar
  8. Chang, T. M. S., Macintosh, F. C., and Mason, S. G. 1966: Semipermeable aqueous microcapsules. I. Prepara- tions and properties. Canad. J. Physiol. Pharmacol. 44: 115.CrossRefGoogle Scholar
  9. Chang, T. M. S., Pont, A., Johnson, L. J., and Malave, N. 1968: Response to intermittent extracorporeal perfusion through shunts containing semipermeable microcapsules. Trans. Amer. Soc. Artif. Int. Organs 13: 163.Google Scholar
  10. Chang, T. M. S., and Malave, N. 1970: The development and first clinical use of semipermeable microcapsules (‘artificial cells’) as a compact artificial kidney. Trans. Amer. Soc. Artif. Int. Organs 16: 141.Google Scholar
  11. Chang, T. M. S., Gonda, A. Dirks, J. H., and Malave, N. 1971: Clinical evaluation of chronic intermittent and short term haemoperfusion in patients with chronic renal failure using semipermeable microcapsules (‘artificial cells’) formed from membrane-coated activated charcoal. Trans. Amer. Soc. Art. Int. Organs 17: 246.Google Scholar
  12. Chang, T. M. S., Gonda, A., Dirks, J. H. A., Coffey, J., and Burns, T. 1972: Short-term and long-term main- tenance of eleven uremic patients using the microcapsule artificial kidney. Trans. Amer. Soc. Art. Int. Organs 18.Google Scholar
  13. Chang, T. M. S., Johnson, L. J., and Ransome, O. J. 1967: Semipermeable aqueous microcapsules. IV. Nonthrombo- genic microcapsules with heparin complexed membranes. Canad. J. Physiol. Pharmacol. 45: 705.CrossRefGoogle Scholar
  14. Chang, T. M. S., and Loa, S. K. 1970: Urea removal by urease and ammonia absorbent in the intestine. Physiologist 13: 70.Google Scholar
  15. Conference on Mechanical Surface and Gas Layer Effects on Moving Blood. 1971. Fed. Proc. 30.Google Scholar
  16. Dedrick, R. L., Vantoch, P., Gombos, E. A., and Moore, R. 1967: Kinetics of activated carbon kidney. Trans. Amer. Soc. Artif Int. Organs 13: 236.Google Scholar
  17. DeMyttenaere, M. H., Maher, J. F., and Schreiner, G. E. 1967: Haemoperfusion through a charcoal column for glutethimide poisoning. Trans. Amer. Soc. Artif. Int. Organs 13: 190.Google Scholar
  18. Dunea, G., and Kolff, W. J. 1965: Clinical experience with the Yatzidis charcoal artificial kidney. Trans. Amer. Soc. Artif. Int. Organs 11: 178.CrossRefGoogle Scholar
  19. Dutton, R. C., Dedrick, R. L., and Bull, B. S. 1969: A simple technique for the experimental production of acute platelet deficiency. Throm. Diath. Haemorrh. 21: 367.Google Scholar
  20. Eriksson, J. C., Gillberg, G., and Lagerfren, J. 1967: A new method for preparing nonthrombogenic plastic surfaces. J. Biomed. Mater. Res. 1: 301.CrossRefGoogle Scholar
  21. Gardner, D. L., Falb, R. C., Kim, B. C., and Emmerling, C. 1971: Possible uraemic detoxication via oral-ingested microcapsules. Trans. Amer. Soc. Artif. Int. Organs 17: 239.Google Scholar
  22. Gordon, A. Better, O. S., Greenbaum, M. A., Marantz, L. B., Gral, T., and Maxwell, M. H. 1971: Clinical maintenance haemodialysis with a sorbent-based low-volume dialysate regeneration system. Trans. Amer. Soc. Artif. Int. Organs 17: 253.Google Scholar
  23. Gott, V. L. Whiffen, J. D., and Dutton, R. C. 1963: Heparin bonding on colloidal graphite surfaces. Science 142: 1297.CrossRefGoogle Scholar
  24. Gott, V. L., Loepke, D. E., Daggett, R. L., Zarnstorff, W., and Young, W. P. 1961: Coating of intravascular plastic prostheses with colloidal graphite. Surgery 50: 382.Google Scholar
  25. Grode, G. A., Anderson, S. J., Grotta, H. M., and Falb, R. D. 1969: Trans. Am. Soc. Artif. Int. Organs 15: 1.Google Scholar
  26. Hagstam, K. E., Larsson, L. E., and Thysell, H. 1966: Experimental studies on charcoal haemoperfusion in phenobarbital intoxication and uraemia, including histological findings. Acta. Med. Scand. 180: 593.CrossRefGoogle Scholar
  27. Hufnagel, C. A., Conrad, P. W., Gillespie, J. F., Pifarre, R., Illano, A., and Yokoyama, T. 1967: Comparative studies of cardiac and vascular implants in relation to thrombosis. Surgery 61: 11.Google Scholar
  28. Leininger, R. L, Cooper, C. W., Falb, R. D., and Grode, C. A. 1966: Non-thrombogenic plastic surfaces. Science 152: 1625.CrossRefGoogle Scholar
  29. Levine, S. N., and Lacrouse, W. C. 1967: Materials and design consideration for a compact artificial kidney. J. Biomed. Materials Res. 1: 275.CrossRefGoogle Scholar
  30. Levowitz, B. S., Laguerre, J. N., Gould, F. E., Scheerer, J., and Schoenfeld, H. 1968: Biologic compatibility and applications of hydron. Trans. Amer. Soc. Artif. Intern. Organs 14: 82.Google Scholar
  31. Lyman, D. J., Andrade, J. D.,Klein, K.G., Brash, J. J.,Fritzinger, B. K., and Bonomo, F. S. (in press): Interaction of platelets with protein surface. Thromb. Diath. Hemorrh. Suppl.Google Scholar
  32. Lyman, D. J., Brash, J. L., and Klein, K. G. 1969: p. 113 in ‘Proceedings Artificial Heart Program Conference’ (Ed R. J. Hegyeli). U.S. Govt. Printing Office, Washington, D.C.Google Scholar
  33. Lyman, D. J., Klein, K. G., Brash, J. L., and Fritzinger, B. K. 1970: The interaction of platelets with polymer surfaces. 1. Uncharged hydrophobic polymer surfaces. Thromb. Diath. Haemorrh. 23: 120.Google Scholar
  34. Lyman, D. J., Muir, W. M., and Lee, I. J. 1965: Effect of chemical structure and surface properties of polymers on the coagulation of blood. 1. Surface free energy effects. Trans. Amer. Soc. Artif. Int. Organs 11: 301.CrossRefGoogle Scholar
  35. Merrill, E. A., Salzman, E. W., Lipps, B. J., Gilliland, E. R., Austen, W. G., and Jolson, J. 1966: Antithrombo genic cellulose membranes for blood dialysis. Trans. Amer. Soc. Artif. Intern. Organs 12: 139.Google Scholar
  36. Merrill, E. W., Salzman, E. W., Long, P. S. L., and Ashford, T. P. 1970: Polyvinyl alcohol-heparin hydrogel `G’. J. Appl. Physiol. 29: 723.Google Scholar
  37. Milligan, H. L., Davis, J., and Edmark, K. W. 1968: The search for correlation between electrokinetic phenomena and blood thrombus formation on implant materials. J. Biomed. Mat. Res. 21: 51.CrossRefGoogle Scholar
  38. Muir, W. M., Martin, A. M., Gilchrist, T., and CourtneyJ. M. 1973: The risk in estimating biocompatibility in ‘Perspectives in Biomedical Engineering’(Ed. R. M. Kenedi). Macmillan, London.Google Scholar
  39. Musolf, M. C., Hulce, V. D., Bennett, D. R., and Rano, M. 1969: Trans. Amer. Soc. Artif. Intern. Organs 15: 18.Google Scholar
  40. Nemchin, R. G., Patel, A. R.,Abel, H. I., Sims, L., and Speaker, M. 1969: Proceedings Artificial Heart Program Conference.Google Scholar
  41. Packham, M. A., Evans, G., Glynn, M. F., and Mustard, J. F. 1969: Effect of plasma proteins on interaction of platelets with glass surfaces. J. Lab. Clin. Med. 73: 686.Google Scholar
  42. Salzman, E. W., Merrill, E. W., Binder, A., Wolf, C. F. W., Ashford, T. P., and Austen, W. G. 1969: Protein-platelet interaction on heparinized surfaces. J. Biomed. Mat. Res. 3: 69.CrossRefGoogle Scholar
  43. Sawyer, P. N., and Pate, J. W. 1953: Bioelectric phenomena as an etiologic factor in intravascular thrombosis. Amer. J. Physiol. 175: 103.Google Scholar
  44. Sawyer, P. N., and Srinivasan, S. 1967: Metallic and plastic prosthetic devices as vascular wall substitutes: biophysical criteria and methods for evaluation. J. Biomed. Mat. Res. 1: 83.CrossRefGoogle Scholar
  45. Sharp, W. V., Gardner, D. L., Andresen, G. J., and Wright, J. 1968: Electrolour: a new vascular interface. Trans. Amer. Soc. Artif. Intern. Organs 14: 73.Google Scholar
  46. Sparks, R. E., Mason, N. S., Meier, P. M., Litt, M. H., and Lindan, O. 1971: Removal of uraemic waste metabolites from the intestinal tract by encapsulated carbon and oxidised starch. Trans. Amer. Soc. Artif. Int. Organs 17: 229.Google Scholar
  47. Sparks, R. E., Salemme, R. M., Meier, P. M., Litt, M. H., and Lindan, O. 1969: Removal of waste metabolites in uraemia by microencapsulated reactants. Trans. Amer. Soc. Artif. Int. Organs 15: 353.Google Scholar
  48. Vroman, L., and Adams, A. L. 1969: Effect of heparin on reactions at aminated polymer-blood interfaces. J. Colloid Interface Sci. 31, 188.CrossRefGoogle Scholar
  49. Vroman, L. Adams, A. L., and Lings, M. 1971: Interactions among human blood proteins at interfaces. Fed. Proc. 30: 1494.Google Scholar
  50. Yatzidis, H. 1964: A convenient haemoperfusion micro-apparatus over charcoal for the treatment of endogenous and exogenous intoxications. Proc. Europ. Dialysis Transplant. Ass. 1: 83.Google Scholar

Copyright information

© Bioengineering Unit, University of Strathclyde 1973

Authors and Affiliations

  • T. M. S. Chang
    • 1
  1. 1.Faculty of MedicineMcGill UniversityMontrealCanada

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