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Preliminary Studies on Mechanochemical-structure Relationships in Connective Tissues Using Enzymolysis Techniques

  • A. S. Hoffman
  • L. A. Grande
  • P. Gibson
  • J. B. Park
  • C. H. Daly
  • P. Bornstein
  • R. Ross

Abstract

In recent studies we have investigated the contribution of the individual components of connective tissues such as artery and ligament to the mechanical behaviour of the whole tissue. Our basic approach is to remove each component of the tissue selectively, using enzymes. The effects of such enzymatic digestions were measured mechanically and were observed histologically by light and electron microscope. Some experiments were performed by applying a sequence of enzymatic treatments to the same specimen; the reversible (low-strain) elastic modulus before and after each step in the sequence was then measured. In some cases only one enzyme was used on a fresh specimen.

Keywords

Collagen Fibre Strain Region Initial Modulus Reversible Region Enzyme Sequence 
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References

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Copyright information

© Bioengineering Unit, University of Strathclyde 1973

Authors and Affiliations

  • A. S. Hoffman
  • L. A. Grande
  • P. Gibson
  • J. B. Park
  • C. H. Daly
  • P. Bornstein
  • R. Ross
    • 1
  1. 1.University of WashingtonSeattleUSA

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