Basic Biochemistry and Control of Production of Cyclic Amp

  • K. J. Hittelman
  • R. W. Butcher
Chapter
Part of the Biological Council book series (BCSDA)

Abstract

In 1957, Rall, Sutherland, and Berthet, [1] reporting the effects of epinephrine and glucagon on phosphorylase activation in liver homogenates, stated that:

‘... the response of the homogenates to the hormones occurred in two stages. In the first stage, a particulate fraction of homogenates produced a heat-stable factor in the presence of hormones; in the second stage, this factor stimulated the formation of liver phosphorylase in supernatant fractions of homogenates in which the hormones themselves were inactive.’

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Copyright information

© Institute of Biology Endowment Fund 1971

Authors and Affiliations

  • K. J. Hittelman
    • 1
  • R. W. Butcher
    • 1
  1. 1.Department of Biochemistry, School of MedicineUniversity of MassachusettsWorcesterUSA

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