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Basic Biochemistry and Control of Production of Cyclic Amp

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Effects of Drugs on Cellular Control Mechanisms

Part of the book series: Biological Council ((BCSDA))

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Abstract

In 1957, Rall, Sutherland, and Berthet, [1] reporting the effects of epinephrine and glucagon on phosphorylase activation in liver homogenates, stated that:

‘... the response of the homogenates to the hormones occurred in two stages. In the first stage, a particulate fraction of homogenates produced a heat-stable factor in the presence of hormones; in the second stage, this factor stimulated the formation of liver phosphorylase in supernatant fractions of homogenates in which the hormones themselves were inactive.’

Supported by Grant AM-13904 from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Biochemistry, School of Medicine, University of Massachusetts, Worcester, Massachusetts, USA

    K. J. Hittelman & R. W. Butcher

Authors
  1. K. J. Hittelman
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  2. R. W. Butcher
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, University College, London, UK

    B. R. Rabin

  2. Biology Laboratory, University of Kent, Canterbury, UK

    R. B. Freedman

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© 1971 Institute of Biology Endowment Fund

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Hittelman, K.J., Butcher, R.W. (1971). Basic Biochemistry and Control of Production of Cyclic Amp. In: Rabin, B.R., Freedman, R.B. (eds) Effects of Drugs on Cellular Control Mechanisms. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-01321-0_8

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