Aflatoxin Metabolism

  • I. F. H. Purchase
  • M. Steyn


Aflatoxin B1, a carcinogenic metabolite of the fungus Aspergillus flavus, is acutely toxic to a number of species, including rats. Male rats (LD50 7·2 mg/kg) are more susceptible to the acute oral effects of aflatoxin than are females (LD50 17·9 mg/kg).1 Aflatoxin B1 is metabolised to aflatoxin M1 which is present in the blood and urine of dosed rats,2 and in the milk of lactating rats, sheep and cows ingesting aflatoxin.34


Castrate Male Carcinogenic Metabolite Nutritional Disease Bolic Product South African Medical Research Council 
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Copyright information

© South African Medical Research Council 1971

Authors and Affiliations

  • I. F. H. Purchase
    • 1
  • M. Steyn
    • 2
  1. 1.National Institute for Nutritional Diseases South African Medical Research CouncilSouth Africa
  2. 2.Division of ToxicologyNational Institute for Nutritional DiseasesSouth Africa

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