Aflatoxin B1, a carcinogenic metabolite of the fungus Aspergillus flavus, is acutely toxic to a number of species, including rats. Male rats (LD50 7·2 mg/kg) are more susceptible to the acute oral effects of aflatoxin than are females (LD50 17·9 mg/kg).1 Aflatoxin B1 is metabolised to aflatoxin M1 which is present in the blood and urine of dosed rats,2 and in the milk of lactating rats, sheep and cows ingesting aflatoxin.3’ 4
KeywordsCastrate Male Carcinogenic Metabolite Nutritional Disease Bolic Product South African Medical Research Council
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