The Effect of Aflatoxin B1, Aflatoxin B2 and Sterigmatocystin on Nuclear Deoxyribonucleases from Rat and Mouse Livers

  • M. J. Pitout
  • H. A. Mcgee
  • J. C. Schabort


There have been a number of in vitro and in vivo studies on the effects of various potent carcinogens such as the butter-yellow-type carcinogens, urethane, γ-butyrolactone and diepoxybutane on the activity of pancreatic DNase I. In these studies, considerable increases in activity were found as a result of treatment with the carcinogens.1, 2 With weak carcinogens no activation of pancreatic DNase I was observed. The potent carcinogens have been found to be devoid of any effect on the activity of spleen DNase II. However, Lesca et a1. 3 decisively demonstrated a sharp rise in pulmonary DNase II activity when rats were treated with the carcinogen benz-3,4-pyrene.


Mouse Liver Sephadex Column Bile Duct Cell South African Medical Research Council Pancreatic DNase 
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Copyright information

© South African Medical Research Council 1971

Authors and Affiliations

  • M. J. Pitout
    • 1
  • H. A. Mcgee
    • 1
  • J. C. Schabort
    • 2
  1. 1.Division of ToxicologyNational Institute for Nutritional Diseases South African Medical Research CouncilSouth Africa
  2. 2.Department of BiochemistryRand Afrikaans UniversityJohannesburgSouth Africa

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