The Effects of Aflatoxin B1 and Sterigmatocystin on Two Different Types of Cell Cultures

  • Johanna C. Engelbrecht


Sterigmatocystin was isolated in 1954 from Aspergillus versicolor and structurally identified in 1962.1 This mycotoxin is chemically closely related to the aflatoxins. Dickens et al.2 have shown it to be carcinogenic on sub­cutaneous injection in rats and Purchase and Van der Watt3 found it to be hepatocarcinogenic on oral administration. Sterigmatocystin is, however, 200 times less carcinogenic than aflatoxin B1, on subcutaneous injection in Wistar rats and 10 times less on oral administration. Holzapfel et al.4 isolated sterigmatocystin from two additional moulds: Aspergillus nidulans and Bipolaris sp. It is produced in much larger quantities than aflatoxins and although less toxic in experimental animals, it may be as hazardous to human health as aflatoxin B1.


Giant Cell Aspergillus Nidulans Orotic Acid Aspergillus Versicolor Chromatin Material 
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Copyright information

© South African Medical Research Council 1971

Authors and Affiliations

  • Johanna C. Engelbrecht
    • 1
  1. 1.Division of ToxicologyNational Institute for Nutritional Diseases South African Medical Research CouncilSouth Africa

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