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The Effects of Aflatoxin B1 and Sterigmatocystin on Two Different Types of Cell Cultures

  • Johanna C. Engelbrecht

Abstract

Sterigmatocystin was isolated in 1954 from Aspergillus versicolor and structurally identified in 1962.1 This mycotoxin is chemically closely related to the aflatoxins. Dickens et al.2 have shown it to be carcinogenic on sub­cutaneous injection in rats and Purchase and Van der Watt3 found it to be hepatocarcinogenic on oral administration. Sterigmatocystin is, however, 200 times less carcinogenic than aflatoxin B1, on subcutaneous injection in Wistar rats and 10 times less on oral administration. Holzapfel et al.4 isolated sterigmatocystin from two additional moulds: Aspergillus nidulans and Bipolaris sp. It is produced in much larger quantities than aflatoxins and although less toxic in experimental animals, it may be as hazardous to human health as aflatoxin B1.

Keywords

Giant Cell Aspergillus Nidulans Orotic Acid Aspergillus Versicolor Chromatin Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bullock, E., Roberts, J.C. and Underwood, J.G. (1962). J. Chem. Soc. 4179.Google Scholar
  2. 2.
    Dickens, F., Jones, H. E. H. and Waynforth, H. B. (1966). Br. J. Cancer, 20, 134.PubMedCentralCrossRefPubMedGoogle Scholar
  3. 3.
    Purchase, I. F. H. and Van Der Watt, J. J. (1968). Fd. Cosmet. Toxicol., 6, 555.CrossRefGoogle Scholar
  4. 4.
    Holzapfel, C. W., Purchase, I. F. H., Steyn, P. S. and Gouws, L. (1966). S.A. med. J., 40, 1100.Google Scholar
  5. 5.
    Zuckerman, A. J., Tsiquaye, K. N. and Fulton, F. (1967). Br. J. exp. Path., 48, 20.Google Scholar
  6. 6.
    Legator, M. (1966). Bacteriol. Rev., 30, 471.PubMedCentralPubMedGoogle Scholar
  7. 7.
    Daniel, M. R. (1965). Brit. J. exp. Path., 46, 183.PubMedCentralPubMedGoogle Scholar
  8. 8.
    Harley, E. H., Rees, K. R. and Cohen, A. (1969). Biochem. J., 114, 289.PubMedCentralCrossRefPubMedGoogle Scholar
  9. 9.
    Engelbrecht, J. C. and Purchase, I. F. H. (1969). S. Afr. med. J., 43, 524.PubMedGoogle Scholar
  10. 10.
    Svoboda, D., Grady, H. J. and Higginson, J. (1966). Am. J. Path., 49, 1023.PubMedCentralPubMedGoogle Scholar
  11. 11.
    Simard, R. and Bernhard, W. (1966). Int. J. Cancer, 1, 463.CrossRefPubMedGoogle Scholar
  12. 12.
    Reynolds, R. C., Montgomery, P. O’B. and Hughes, B. (1964). Cancer Res., 24, 1269.PubMedGoogle Scholar
  13. 13.
    Floyd, L. R., Unuma, T. and Busch, H. (1968). Exp. Cell. Res., 51, 423.CrossRefPubMedGoogle Scholar
  14. 14.
    Lapis, K. and Bernhard, W. (1965). Cancer Res., 25, 628.PubMedGoogle Scholar
  15. 15.
    Lewin, D. K. and Moscarello, M. A. (1968). Lab. Invest., 19, 265.Google Scholar
  16. 16.
    Schabort, J. C. (1969). Personal communication.Google Scholar
  17. 17.
    Nel, W. and Pretorius, H. E. (1970). Biochem. Pharmacol., 19, 957.CrossRefPubMedGoogle Scholar
  18. 18.
    Diamond, L. (1969). Progr. exp. Tumor Res., 11, 364.CrossRefPubMedGoogle Scholar
  19. 19.
    Berwald, Y. and Sachs, L. (1963). Nature (Lond.), 200, 1182.CrossRefPubMedGoogle Scholar
  20. 20.
    Berwald, Y. and Sachs, L. (1965). J. nat. Cancer Inst., 35, 641.PubMedGoogle Scholar
  21. 21.
    Heidelberger, C. and Iype, P. T. (1967). Science, 155, 214.CrossRefPubMedGoogle Scholar
  22. 22.
    Dipaolo, J. A., Donovan, P. and Nelson, R. (1969). J. nat. Cancer Inst., 42, 867.PubMedGoogle Scholar
  23. 23.
    Alfred, L. J., Globerson, A., Berwald, Y. and Prehn, R. T. (1964). Br. J. Cancer, 18, 159.PubMedCentralCrossRefPubMedGoogle Scholar
  24. 24.
    Diamond, L. (1967). Int. J. Cancer, 2, 143.CrossRefPubMedGoogle Scholar
  25. 25.
    Alfred, L. J. (1964). Br. J. Cancer, 18, 159.PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© South African Medical Research Council 1971

Authors and Affiliations

  • Johanna C. Engelbrecht
    • 1
  1. 1.Division of ToxicologyNational Institute for Nutritional Diseases South African Medical Research CouncilSouth Africa

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