The Effects of Aflatoxin B1 and Sterigmatocystin on Two Different Types of Cell Cultures
Sterigmatocystin was isolated in 1954 from Aspergillus versicolor and structurally identified in 1962.1 This mycotoxin is chemically closely related to the aflatoxins. Dickens et al.2 have shown it to be carcinogenic on subcutaneous injection in rats and Purchase and Van der Watt3 found it to be hepatocarcinogenic on oral administration. Sterigmatocystin is, however, 200 times less carcinogenic than aflatoxin B1, on subcutaneous injection in Wistar rats and 10 times less on oral administration. Holzapfel et al.4 isolated sterigmatocystin from two additional moulds: Aspergillus nidulans and Bipolaris sp. It is produced in much larger quantities than aflatoxins and although less toxic in experimental animals, it may be as hazardous to human health as aflatoxin B1.
KeywordsGiant Cell Aspergillus Nidulans Orotic Acid Aspergillus Versicolor Chromatin Material
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