Production of Citreoviridin, a Neurotoxic Mycotoxin of Penicillium Citreo-Viride Biourge
the ethanol extract of P. citreo-viride Biourge was actually neurotoxic to several animals, causing the same symptoms as those noted in acute cardiac beriberi;
a marked drop in the high incidence of ‘Shoshin-kakke’ in Japan occurred in 1910 although the discovery of vitamins occurred 1 year later and their usage in practical medicine only a further 10 years later, indicating that avitaminosis is not acceptable as a reasonable theory for the cause of ‘Shoshin-kakke’;
when rice inspection conducted by the Ministry of Agriculture was introduced in major rice-producing districts in about 1910 the high incidence of ‘Shoshin-kakke’ also decreased. Thus, intake of ungraded rice or mouldy rice is presumably a suspected causative factor in the disease.6 For these reasons Dr Uraguchi,6,7,8 has stressed that acute cardiac beriberi is caused by mycotoxic intoxication originating from the metabolite(s) of P. citreo-viride Biourge.
KeywordsEthanol Extract Polished Rice Lethal Toxicity Brilliant Yellow Czapek Medium
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