Skip to main content

Cholinergic inhibitory mechanism in the cerebral cortex

  • Chapter
  • 21 Accesses

Abstract

Numerous investigations have been concerned with demonstrating the role of chemical substances, especially acetylcholine, in central synaptic transmission. The results are conclusive for Renshaw cells, but are only suggestive for the cerebral cortex.

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amassian, V. E., Waller, H. J. and Macy, Jr. J. (1964). ‘Neural mechanism of the primary somatosensory evoked potentials’, Ann. N. Y. Acad. Sci., 112, 5–32

    Article  PubMed  CAS  Google Scholar 

  • Bhargava, V. K. (1974). ‘Blockade by eserine of the cerebral cortical effects of alloferine— a further evidence of cortical cholinergic inhibitory mechanism’, Jap. j. Pharmac., 24, 1–4

    Article  CAS  Google Scholar 

  • Bhargava, V. K., Horton, R. W. and Meldrum B. S. (1970). ‘Long-lasting convulsant effect on the cerebral cortex of Naja naja venom’, Br. J. Pharmac., 39, 455–461

    Article  CAS  Google Scholar 

  • Bhargava, V. K. and Meldrum, B. S. (1969). ‘The strychnine like action of curare and related compounds on the somatosensory evoked responses of the rat cortex’, Br. J. Pharmac., 37, 112–122

    Article  CAS  Google Scholar 

  • Bhargava, V. K. and Meldrum, B. S. (1971). ‘Blockade by eserine of the cerebral cortical effects of strychnine and curare’, Nature, 230, 152

    CAS  Google Scholar 

  • Chang, H. T. (1953). ‘Similarity in action between curare and strychnine on cortical neurones’, J. Neurophysiol., 14, 23–28

    Google Scholar 

  • Colonnier, M. (1966). ‘The structural design of the neocortex’, in Brain and Conscious Experience, (Eccles, J. C., Ed.) 1–23, Springer, New York

    Google Scholar 

  • Curtis, D. R., Hösli, L. and Johnston, G. A. R. (1967). ‘Inhibition of spinal neurones by glycine’, Nature, 215, 1502–1503

    Article  PubMed  CAS  Google Scholar 

  • Curtis, D. R., Hösli, L. Johnston, G. A. R. and Johnston, I. H. (1968). ‘The hyperpolarization of spinal motoneurones by glycine and related aminoacids’, Expl Brain. Res., 5, 235–258

    Article  CAS  Google Scholar 

  • Feldberg, W., Malcolm, J. L. and Sherwood, S. L. (1956). ‘Some effects of tubocurarine on the electrical activity of cats’ brain’, J. Physiol. Lond., 132, 130–145

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Kelly, J. S. and Krnjevié, K. (1968). ‘Effect of gamma aminobutyric acid and glycine on cortical neurones’, Nature, 219, 1380–1381

    Article  PubMed  CAS  Google Scholar 

  • Krnjevié, K. and Phillis, J. W. (1961). ‘Sensitivity of cortical neurones to acetylcholine’, Experientia, 17, 469

    Article  Google Scholar 

  • Krnjevié, K. and Phillis, J. W. (1963). ‘Acetylcholine sensitive-cells in the cerebral cortex’, J. Physiol., Lond., 166, 296–327

    Article  Google Scholar 

  • Phillis, J. W. and York, D. H. (1967a). ‘Cholinergic inhibition in the cerebral cortex’, Brain. Res., 5, 517–520

    Article  PubMed  CAS  Google Scholar 

  • Phillis, J. W. and York, D. H. (1967b). ‘Strychnine Vock of neural and drug induced inhibition in the cerebral cortex’, Nature, 216, 922–923

    Article  PubMed  CAS  Google Scholar 

  • Phillis, J. W. and York, D. H. (1968). ‘Pharmacological studies on a cholinergic inhibition in the cerebral cortex’, Brain Res. 10, 297–306

    Article  PubMed  CAS  Google Scholar 

  • Szentagothai, J. (1964). ‘The use of degeneration methods in investigations of short neurones and neuronal connexions’, in Degeneration patterns in the nervous system, Progress in brain Research Vol. 14, (Singer, M. and Schade, J. P., Eds.) 1–32, Elsevier, Amsterdam

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Copyright information

© 1976 The Contributors

About this chapter

Cite this chapter

Bhargava, V.K. (1976). Cholinergic inhibitory mechanism in the cerebral cortex. In: Bradley, P.B., Dhawan, B.N. (eds) Drugs and Central Synaptic Transmission. Palgrave, London. https://doi.org/10.1007/978-1-349-01247-3_7

Download citation

Publish with us

Policies and ethics