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Studies on the role of brain monoamines in the potentiation of morphine analgesia by monoamine oxidase inhibitors nialamide and mangiferin in albino rats

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Drugs and Central Synaptic Transmission

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Abstract

Monoamine oxidase (MAO) inhibitor-induced potentiation of the pharmacological actions and toxicity of meperidine, in man and experimental animals, is well documented (for literature see Penn and Rogers, 1971). The same is not true for morphine. There are reports which suggest that unlike meperidine, morphine toxicity in man is seldom enhanced by prior treatment with MAO inhibitors (Palmer, 1960; Shee, 1960; Brown and Waldron, 1962). Other workers (Mustala and Jounela, 1966; Rogers and Thornton, 1969; Bhattacharya, Raina, Banerjee and Neogy, 1971; Yeh and Mitchell, 1971), however, have shown that MAO inhibitors do potentiate the pharmacological actions and toxicity of morphine in experimental animals.

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Authors and Affiliations

  1. Department of PharmacologyInstitute of Medical Sciences and Department of Pharmaceutics, Institute of TechnologyBanaras Hindu University, Varanasi, India

    S. K. Bhattacharya, A. K. Sanyal & S. Ghosal

Authors
  1. S. K. Bhattacharya
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  2. A. K. Sanyal
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  3. S. Ghosal
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Editor information

Editors and Affiliations

  1. Department of Pharmacology (Preclinical), Medical School, Birmingham, UK

    P. B. Bradley

  2. Division of Pharmacology, Central Drug Research Institute, Lucknow, India

    B. N. Dhawan

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© 1976 The Contributors

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Bhattacharya, S.K., Sanyal, A.K., Ghosal, S. (1976). Studies on the role of brain monoamines in the potentiation of morphine analgesia by monoamine oxidase inhibitors nialamide and mangiferin in albino rats. In: Bradley, P.B., Dhawan, B.N. (eds) Drugs and Central Synaptic Transmission. Palgrave, London. https://doi.org/10.1007/978-1-349-01247-3_33

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