Abstract
The hypothalamus is very rich in acetylcholine (ACh) (Feldberg and Vogt, 1948), monoamines (Twarog and Page, 1953; Carlsson, 1959) and histamine (Adam, 1961). The distribution of synthesising and catabolising enzymes for these neurohumours has been mapped out in the central nervous system including the hypothalamic area (Koelle and Geesey, 1961; Adam, Hye and Waton, 1964). Histochemical localisation for some of these amines has also been accomplished (Fuxe, Hökfelt and Ungerstedt, 1969) suggesting a neurotransmitter role for these biogenic amines. Furthermore, ACh and histamine have been shown to induce a central release of antidiuretic hormone (ADH) (Pickford, 1947 ; Blackmore and Cherry, 1955) . Adrenoceptive drugs, however, have been shown to facilitate as well as inhibit the release of ADH (O’Connor and Verney, 1945) and oc-adrenoceptor blocking agents have been shown to block the evoked antidiuretic response (Mills and Wang, 1964). Moreover, monoamine nerve terminals richly innervate the supraoptic nucleus which contains the soma of terminal neurosecretory neurones (Carlsson, Falck and Hillarp, 1962). The foregoing observations suggest involvement of ACh, monoamines and histamine in the central control of ADH release. The present investigation was undertaken to characterise, by pharmacological means, the central receptors governing antidiuretic hormone release.
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Kulshrestha, V.K., Srivastava, Y.P., Bhargava, K.P. (1976). Pharmacological characterisation of central receptors in the release of antidiuretic hormone. In: Bradley, P.B., Dhawan, B.N. (eds) Drugs and Central Synaptic Transmission. Palgrave, London. https://doi.org/10.1007/978-1-349-01247-3_24
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DOI: https://doi.org/10.1007/978-1-349-01247-3_24
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