Abstract
The hypothalamus is very rich in acetylcholine (ACh) (Feldberg and Vogt, 1948), monoamines (Twarog and Page, 1953; Carlsson, 1959) and histamine (Adam, 1961). The distribution of synthesising and catabolising enzymes for these neurohumours has been mapped out in the central nervous system including the hypothalamic area (Koelle and Geesey, 1961; Adam, Hye and Waton, 1964). Histochemical localisation for some of these amines has also been accomplished (Fuxe, Hökfelt and Ungerstedt, 1969) suggesting a neurotransmitter role for these biogenic amines. Furthermore, ACh and histamine have been shown to induce a central release of antidiuretic hormone (ADH) (Pickford, 1947 ; Blackmore and Cherry, 1955) . Adrenoceptive drugs, however, have been shown to facilitate as well as inhibit the release of ADH (O’Connor and Verney, 1945) and oc-adrenoceptor blocking agents have been shown to block the evoked antidiuretic response (Mills and Wang, 1964). Moreover, monoamine nerve terminals richly innervate the supraoptic nucleus which contains the soma of terminal neurosecretory neurones (Carlsson, Falck and Hillarp, 1962). The foregoing observations suggest involvement of ACh, monoamines and histamine in the central control of ADH release. The present investigation was undertaken to characterise, by pharmacological means, the central receptors governing antidiuretic hormone release.
This is a preview of subscription content, log in via an institution.
Preview
Unable to display preview. Download preview PDF.
References
Adam, H. M. (1961). ‘Histamine in the central nervous system and hypophysis of the dog’, in Regional Neurochemistry. (Kety, S. S. and Elkes, J., Eds.) 293–306
Tergamon Press, Oxford Adam, H. M., Hye, H. K. A. and Waton, N. G. (1964). ‘Studies on uptake and formation of histamine by hypophysis and hypothalamus in the cat’, J. Physiol., Lond., 175, 70–71
Bhargava,K.P.,Kulshrestha,V.K. and Srivastava, Y.P.(1972).‘Central cholinergic and adrener-gic mechanisms in the releas of antidiuretic hormone’,Br.J.Pbarmac., 44,617–627
Bhargava, K. P., Kulshrestha, V. K., Santhakumari, G. and Srivastava, Y. P. (1973). ‘Mechanism of histamine-induced antidiuretic response’, Br. J. Pharmac., 47, 700–705
Bhargava, K. P. and Tangri, K. K. (1959). ‘Central vasomotor effects of 5-hydroxytryptamine’, Br. J. Pharmac. Chemother., 14, 411–414
Blackmore, W. P. and Cherry, C. R., (1955). ‘Antidiuretic action of histamine in the dog’, Am. J. Physiol., 180, 596–598
Carlsson, A. (1959). ‘The occurrence, distribution and physiological role of catecholamine in the nervous system’, Pharmac. Rev., 11, 490–493
Carlsson, A., Falck, B. and Hillarp, N. A. (1962). ‘Cellular localization of brain monoamines’, Acta physiol. scand., 196: Suppl. 56, 1–28
Dicker, S. E. (1953). ‘A method for the assay of very small amounts of antidiuretic activity with a note on antidiuretic titre of rat blood’, Physiol., Land., 122, 149–157
Feldberg, W. and Vogt, M. (1948). ‘Acetylcholine in different regions of central nervous system’, J. Physiol., Lond., 107, 372–378
Fuxe, K., Hökfelt, T. and Ungerstedt, U. (1969). ‘Distribution of monoamines in the mammalian central nervous system by histochemical studies’, in Metabolism of Amines in the Brain. Symposium of the British and Scandinavian Pharmacological Society, Edinburgh, 1968, ( Hooper, G., Ed.) 10–12, Macmillan, London
Heller, H. and Ginsburg, M. (1966). ‘Secretion, metabolism and fate of the posterior pituitary hormones’, in The Pituitary Gland, Vol. 3 ( Harris, G. W. and Donovan, B. Y., Eds.) 355–366, Butterworths, London.
Koelle, G. B. and Geesey, G. (1961). ‘Localization of acetylcholinesterase in the neurohypophysis and its functional implications’, Proc. Soc. exp. Biol. Med., 106, 625–628
Mills, E. and Wang, S. C. (1964). ‘Pharmacological blockade of ascending pathways’, Am. J. Physiol., 207, 1405–1410
O’Connor, W. J. and Verney, E. B. (1945). ‘The effect of increased activity of the sympathetic system in inhibition of water diuresis by emotional stress’, Q.11. exp. Physiol., 33, 77–90
Philippu, A., Heyd, G. and Burger, A. (1970). ‘Release of noradrenaline from the hypothalamus in vivo’, Eur. J. Pharmac., 9, 52–58
Pickford, M. (1947). ‘The inhibitory effect of acetylcholine in the supraoptic nucleus of chloralosed dog’, J. Physiol., Lond., 106, 264–270
Statt, W. H. and Chenoweth, M. B. (1966). ‘Release of catecholamines by vasopressin into the cavernous sinus blood of the dog’, Proc. Soc. exp. Biol. Med., 123, 785–788
Twarog, B. M. and Page, I. H. (1953). ‘Serotonin content of some mammalian tissues and urine and a method of its determination’, Am. J. Physiol., 175, 157–161
Yoshida, A. S., Motohashi, K., Ibayashi, M. and Okinaka, S. (1963). ‘Method for the assay of antidiuretic hormone in plasma with a note on the antidiuretic titre of human plasma’, J. Lab. clin. Med., 62, 279–285
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1976 The Contributors
About this chapter
Cite this chapter
Kulshrestha, V.K., Srivastava, Y.P., Bhargava, K.P. (1976). Pharmacological characterisation of central receptors in the release of antidiuretic hormone. In: Bradley, P.B., Dhawan, B.N. (eds) Drugs and Central Synaptic Transmission. Palgrave, London. https://doi.org/10.1007/978-1-349-01247-3_24
Download citation
DOI: https://doi.org/10.1007/978-1-349-01247-3_24
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-01249-7
Online ISBN: 978-1-349-01247-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)