Microelectrophoretic studies on neurones in the Clarke’s column
The response of mammalian central neurones to various drugs applied into their environment by microelectrophoresis has been widely studied (Curtis and Johnston, 1974; Krnjević, 1974). We have studied the chemical sensitivity of individual Clarke’s column neurones to putative acidic amino acid neurotransmitters (l-glutamic and l-aspartic acids) and acetylcholine (ACh). This work was supplemented by pharmacological studies using L-glutamic acid diethylester and l-methionine-dl-sulphoximine as possible excitatory amino acid antagonists.
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