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Drugs and Central Synaptic Transmission pp 227–234Cite as

Pharmacological profile of inhibition in the vestibular and ocular nuclei

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Abstract

There is now considerable evidence for the involvement of y-aminobutyric acid (GABA) as an inhibitory (Curtis and Felix, 1971; Curtis, Duggan, Felix, Johnston and McLennan, 1971; Krnjevie and Schwartz, 1967; Straughan, Neal, Simmonds, Collins and Hill, 1971) and possibly excitatory (Davidoff, 1972; DeGroat, 1969; Shank, Pong, Freeman and Graham, 1974) transmitter in many areas of the vertebrate central nervous system (CNS). In the past few years we have strengthened the GABA hypothesis in the supraspinal areas of the mammalian vestibular and oculomotor system because they offer the unique opportunity to study identified physiological pathways by both intracellular and extracellular recordings (Ito, Highstein and Tsuchiya, 1970; Baker, Mano and Shimazu, 1969; Precht, Baker and Okada, 1973a; Precht, Schwindt and Baker, 1973b). This paper will review and present new evidence on the use of pharmacological agents to elucidate the nature of the inhibitory synaptic transmitter (s) in the ocular and vestibular nuclei.

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Author information

Authors and Affiliations

  1. Division of Neurobiology, Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa, 52240, USA

    R. Baker

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  1. R. Baker
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Editor information

Editors and Affiliations

  1. Department of Pharmacology (Preclinical), Medical School, Birmingham, UK

    P. B. Bradley

  2. Division of Pharmacology, Central Drug Research Institute, Lucknow, India

    B. N. Dhawan

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© 1976 The Contributors

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Baker, R. (1976). Pharmacological profile of inhibition in the vestibular and ocular nuclei. In: Bradley, P.B., Dhawan, B.N. (eds) Drugs and Central Synaptic Transmission. Palgrave, London. https://doi.org/10.1007/978-1-349-01247-3_21

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