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The use of transmitter antagonists in microelectrophoretic investigations of central synaptic transmission

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Drugs and Central Synaptic Transmission

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Abstract

There is now adequate evidence to accept a number of compounds as transmitters in the mammalian central nervous system. This paper is concerned with pharmacological interference with transmitter action and discusses micro-electrophoretic methods, since investigations in which selective antagonists of a particular transmitter process are administered close to synapses may be useful in establishing the nature of the transmitter and may provide information of therapeutic significance. As might be expected I shall concentrate on acetylcholine and the amino acid transmitters, since the evidence for noradrenaline, dopamine, 5-hydroxytryptamine and certain polypeptides as transmitters seems to be based more on neurochemical findings and evidence of excitation or inhibition of neurones, rather than on the use of selective antagonists.

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Authors and Affiliations

  1. Department of Pharmacology, Australian National University, Canberra, ACT, Australia

    D. R. Curtis

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  1. D. R. Curtis
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Editors and Affiliations

  1. Department of Pharmacology (Preclinical), Medical School, Birmingham, UK

    P. B. Bradley

  2. Division of Pharmacology, Central Drug Research Institute, Lucknow, India

    B. N. Dhawan

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Curtis, D.R. (1976). The use of transmitter antagonists in microelectrophoretic investigations of central synaptic transmission. In: Bradley, P.B., Dhawan, B.N. (eds) Drugs and Central Synaptic Transmission. Palgrave, London. https://doi.org/10.1007/978-1-349-01247-3_2

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