Skip to main content

Liver Cell Injury by Beryllium

  • Chapter
A Symposium on Mechanisms of Toxicity

Part of the book series: Biological Council ((BCSDA))

  • 20 Accesses

Abstract

A detailed mechanistic understanding in molecular terms of how living cells and tissues respond to acute and/or chronic chemical injury has always been of great interest. Today, in a world that becomes increasingly aware of and concerned with toxic hazards in our environment such knowledge becomes indispensable. The real and/or alleged dangers to human health from a wide variety of pollutants have to be assessed on an intelligent and rational basis. Exploring in depth how selected toxic agents produce changes in living organisms and the elucidation of the detailed mechanisms of toxicity hopefully will help us towards achieving this goal. The study of the experimental toxicology of beryllium (Be), especially of Be-induced liver cell injury, offers some definite advantages which justify its choice as a model system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bassleer, R. (1965). C. R. Soc. Biol. Paris, 159, 1620

    PubMed  CAS  Google Scholar 

  • Bresnick, E. (1965). J. biol. Chem., 240, 2550

    PubMed  CAS  Google Scholar 

  • Bresnick, E., Williams, S. S. & Mosse, H. (1967). Cancer Res., 27, 469

    PubMed  CAS  Google Scholar 

  • Bucher, N. L. R. (1967). New Engl. J. Med., 277, 686–696, 738

    Article  PubMed  CAS  Google Scholar 

  • Cheng, K. K. (1956). J. path. Bact., 71, 265

    Article  PubMed  CAS  Google Scholar 

  • Chèvremont, M. & Firket, H. (1951). C. R. Soc. Biol., Paris, 145, 938

    Google Scholar 

  • de Recondo, A. M. & Fichot, O. (1969). Biochem. biophys. Acta, 186, 340

    Google Scholar 

  • Festy, B., Le Pecq, J. B., Paoletti, C. & Truhaut, R. (1965). Ann. biol. clin., Paris, 23, 37

    CAS  Google Scholar 

  • Harris, H. (1968). Nucleus and Cytoplasm. Oxford: Clarendon Press

    Google Scholar 

  • Higgins, G. M. & Anderson, R. M. (1931). Arch. Path., 12, 186

    Google Scholar 

  • Hurwitz, A. & Carter, CH. E. (1969). Mol. Pharmac., 5, 350

    CAS  Google Scholar 

  • Kimmerle, G. (1966). Handbook of Experimental Pharmacology, vol. XXI, ed. Eichler, O., Farah, A., Herken, H. & Welch, A. D. Berlin-Heidelberg New York: Springer-Verlag

    Google Scholar 

  • Labow, R., Maley, G. F. & Maley, F. (1969). Cancer Res., 29, 366

    PubMed  CAS  Google Scholar 

  • Mainigi, K. D. & Bresnick, E. (1969). Biochem. Pharmac., 18, 2003

    Article  CAS  Google Scholar 

  • Polak, L., Barnes, J. M. & Turk, J. L. (1968). Immunology, 14, 707–711

    PubMed  CAS  PubMed Central  Google Scholar 

  • Reid, E. (1967). In Enzyme Cytology, ed. Roodin, D. B. London-New York: Academic Press

    Google Scholar 

  • Schwartz, H. S., Sodergren, J. E., Garofalo, M. & Sternberg, S. S. (1965). Cancer Res., 25, 307

    PubMed  CAS  Google Scholar 

  • Tapp, E. (1966). Br. J. Cancer, 20, 779

    Article  Google Scholar 

  • Tepper, L. B., Hardy, H. L. & Chamberlin, R. I. (1961). Toxicity of Beryllium Compounds, ed. Browning, E. Amsterdam-New York: Elsevier Publishing Co.

    Google Scholar 

  • Thomas, M. & Aldridge, W. N. (1966). Biochem. J., 98, 94

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Tomkins, G. M., Gelehrter, T. D., Granner, D. K., Peterkofsky, B., & Thompson, E. B. (1969). In Exploitable Molecular Mechanisms and Neoplasia, pp. 229–250. Baltimore: The Williams and Wilkins Co.

    Google Scholar 

  • Truhaut, R., Festy, B. & Le Talaer, J. Y. (1968). C. R. Acad. Sci., Paris, 266, 1192

    CAS  Google Scholar 

  • Vorwald, A. J., Reeves, A. L. & Urban, E. C. J. (1966). In Beryllium, its Industrial Hygiene Aspects, ed. Stokinger, H. E. New York-London: Academic Press

    Google Scholar 

  • Witschi, H. P. & Aldridge, W. N. (1967). Biochem. Pharmac. 16, 263

    Article  CAS  Google Scholar 

  • Witschi, H. P. & Aldridge, W. N. (1968). Biochem. J., 106, 811

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Witschi, H. P. (1968). Lab. Invest., 19, 67

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Copyright information

© 1971 Institute of Biology Endowment Fund

About this chapter

Cite this chapter

Witschi, H.P. (1971). Liver Cell Injury by Beryllium. In: Aldridge, W.N. (eds) A Symposium on Mechanisms of Toxicity. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-01085-1_9

Download citation

Publish with us

Policies and ethics