Abstract
Osteolathyrism is an experimentally induced disease of connective tissue which was discovered during an investigation into the cause of human lathyrism; the latter occurs in Indians, occasionally Spaniards and Italians who, during times of starvation, are obliged to live on a diet composed chiefly of the seed of the chick pea, Lathyrus sativus. The result is a complex of symptoms including spinal paralysis; the pathology is unknown but is thought to be due to an upper motor neurone lesion involving both the pyramidal and extra-pyramidal tracts. During the search for the neurotoxic agent, a factor was found in the seeds of the sweet pea, Lathyrus odoratus, and named the lathyrus factor, which when fed to weanling rats produced a disease of the skeleton and connective tissues which has been called osteolathyrism (Geiger et al., 1933) and which apparently bears no relationship to human lathyrism.
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Levene, C.I. (1971). Effect of Lathyrogenic Compounds on the Cross-Linking of Collagen and Elastin in Vivo. In: Aldridge, W.N. (eds) A Symposium on Mechanisms of Toxicity. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-01085-1_5
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DOI: https://doi.org/10.1007/978-1-349-01085-1_5
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