Drug Receptors pp 105-119 | Cite as

Desensitization at the Motor Endplate

  • L. G. Magazanik
  • F. Vyskočil
Chapter
Part of the Biological Council book series

Abstract

The transience of the effect of acetylcholine (ACh) was described more than thirty-five years ago, almost simultaneously with the experimental evidence about the key role of ACh in neuromuscular transmission (Brown, Dale & Feldberg, 1936; Cowan, 1936). The depolarization induced by ACh at the postjunctional membrane of the muscle fibre reaches a maximum and then begins to fall gradually, despite the fact that the ACh concentration remains constant. This phenomenon, named ‘desensitization’ (Thesleff, 1955, 1960), has been observed not only in skeletal muscle but also at other kinds of chemosensitive tissue such as electroplax and nerve cells.

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Copyright information

© Institute of Biology Endowment Trust Fund 1973

Authors and Affiliations

  • L. G. Magazanik
    • 1
  • F. Vyskočil
    • 1
  1. 1.Sechenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR Leningrad, Soviet Union and Institute of Physiology, Czechoslovak Academy of SciencesPragueCzechoslovakia

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