The Permeability Change Produced by Acetylcholine in Smooth Muscle

Bolton, T. B.

doi:10.1007/978-1-349-00910-7_7

T. B. Bolton²

Part of the book series: Biological Council

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Abstract

It is well known that acetylcholine depolarizes the membrane of visceral smooth muscle (Bülbring, 1954, 1955, 1957; Burnstock, 1958; Bülbring & Burnstock, 1960; Bülbring & Kuriyama, 1963; Hidaka & Kuriyama, 1969; Bolton, 1971, 1972), but much less is known about the way in which it does this. The main objective of this paper is to discuss the applicability to the action of acetylcholine on the smooth muscle membrane of a simple model of transmitter action which has been developed from studies on other excitable membranes (Fatt & Katz, 1951; Coombs, Eccles & Fatt, 1955; Takeuchi & Takeuchi, 1960; Takeuchi, 1963a,b; Ginsborg, 1967). Of particular interest will be the permeability to various ion species of the channels which are opened in the membrane when the muscarinic receptor is stimulated. All results were obtained by intracellular recording of membrane potential from the longitudinal muscle of the guinea-pig terminal ileum which was separated from the underlying circular muscle. More details of the method are given elsewhere (Bolton, 1972).

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Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, England
T. B. Bolton

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T. B. Bolton
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Department of Physiology and Biochemistry, University of Southampton, UK
H. P. Rang

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Bolton, T.B. (1973). The Permeability Change Produced by Acetylcholine in Smooth Muscle. In: Rang, H.P. (eds) Drug Receptors. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-00910-7_7

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DOI: https://doi.org/10.1007/978-1-349-00910-7_7
Publisher Name: Palgrave, London
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