Caffeine, Calcium and the Activation of Contraction

  • H. C. Lüttgau
Part of the Biological Council book series


It has been known for some time that caffeine promotes activation and impedes inactivation of phasic muscle fibres. This occurs despite the fact that low concentrations of the drug have no effect on the electrical characteristics of the excitable membrane and on the actomyosin system of striated muscle fibres (Axelsson & Thesleff, 1958; Korey, 1950; Hasselbach, 1953). This leaves some part of the extensive tubular system as the most probable site of drug action (Sandow, 1965). The experiments with isolated muscle fibres described here provide some further information about the effect of caffeine on the coupling mechanism between excitation and contraction (Lüttgau & Oetliker, 1968). They also show how the drug—because of its specific action—can be useful in elucidating the causes of muscular failure (Lobsiger, 1968). References to further publications can be found in a review article by Sandow (1965).


Membrane Potential Potassium Concentration Ringer Solution Maximal Tension Excitable Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Axelsson, J. & Thesleff, S. (1958). Acta physiol. scand., 44, 5CrossRefGoogle Scholar
  2. Bianchi, C. P. (1962). J. Pharmac. exp. Ther., 138, 41Google Scholar
  3. Eberstein, A. & Sandow, A. (1963). In The Effect of Use and Disuse on Neuromuscular Functions p. 515. Prague.Google Scholar
  4. Hasselbach, W. (1953). Z. Naturforsch., 8b, 212Google Scholar
  5. Hodgkin, A. L. & Horowicz, P. (1960). J. Physiol., Lond., 153, 386PubMedCentralCrossRefPubMedGoogle Scholar
  6. Korey, S. (1950). Biochim. biophys. Acta, 4, 58CrossRefPubMedGoogle Scholar
  7. Lobsiger, E. A. (1968). Thesis, Berne UniversityGoogle Scholar
  8. Ttgau, H. C. & Oetliker, H. (1968). J. Physiol., Lond., 194, 51PubMedCentralCrossRefPubMedGoogle Scholar
  9. Mashima, H., Matsumura, M. & Nakayama, Y. (1962). Jap. J. Physiol., 12, 324CrossRefGoogle Scholar
  10. Sandow, A. (1965). Pharmac. Rev., 17, 265Google Scholar
  11. Peachey, L. D. (1965). J. cell Biol., 25, 209PubMedCentralCrossRefPubMedGoogle Scholar
  12. Weber, A. (1968). J. gen. Physiol., 52, 760PubMedCentralCrossRefPubMedGoogle Scholar
  13. Weber, A. & Herz, R. (1968)..1. gen. Physiol. 52, 750Google Scholar

Copyright information

© Palgrave Macmillan, a division of Macmillan Publishers Limited 1970

Authors and Affiliations

  • H. C. Lüttgau
    • 1
  1. 1.Department of Cell PhysiologyRuhr-UniversityBochumGermany

Personalised recommendations