Involvement of Calcium in the Secretion of Catecholamines
The role of calcium as the stimulus-secretion coupling agent in the adrenal medulla has been soundly established in the papers which Douglas and his colleagues have published since 1961 (Douglas, 1968). However, three major questions concerning the calcium-dependent secretion of catecholamines remain unanswered. These are, first, how is calcium entry into chromaffin cells regulated; second, what is the nature of the process activated by calcium; third, how is calcium removed from the cells at the end of the secretory response? Evidence touching upon these three questions is discussed here.
KeywordsChromaffin Cell Adrenal Medulla Secretory Response Free Solution Tyrode Solution
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- Banks, P. (1964). D. Phil. Thesis, OxfordGoogle Scholar
- Carlsson, A., Hillarp, N.-A. & Waldeck, B. (1962). Medina. exp., 6, 47Google Scholar
- Carlsson, A., Hillarp, N.-A. & Waldeck, B. (1963). Acta physiol. scand., 59, suppl. 215, p. 5Google Scholar
- Diner, O. (1967). C.r. hebd. Seanc. Acad. Sci., Paris, 265, 616Google Scholar
- Miele, E. & Rubin, R. P. (1968). J. Pharmac. exp. Ther., 161, 296Google Scholar
- Poisner, A. M. & TrÎfarÓ, J. M. (1967). Mol. Pharmac., 3, 561Google Scholar
- Rubin, R. P., Feinstein, M. B., Jaanus, S. D. & Paimre, M. (1967). J. Pharmac. exp. Ther., 155, 463Google Scholar
- Schümann, H. J. (1958). Arch. exp. Path. Pharmak., 233, 237Google Scholar
- Smith, A. D. (1968). In The Interaction of Drugs and Subcellular Components on Animal Cells, ed. Campbell, P. N., p. 239. London: J. & A. ChurchillGoogle Scholar
- TrÎfarÓ, J. M. & Poisner, A. M. (1967). Mol. Pharmac., 3, 572Google Scholar