Insulin is secreted by the ‘islet tissue’ of the pancreas. In 1889 von Mehring and Minkowski had recognised that the functioning of the pancreas was related to the metabolism of sugar in the body, and by the first decade of this century it was generally realised that the islet tissue produced some sort of chemical messenger secreted into the blood which was responsible for regulating the blood-sugar level. But, before the work of Banting, all attempts to prepare active preparations of this substance had failed.
KeywordsIslet Tissue Chemical Messenger Cerebellar Stimulation Protamine Insulin Alien Property
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