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The Molecular Biology of Inflammatory Breast Cancer

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Inflammatory Breast Cancer

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Abstract

Inflammatory breast cancer (IBC) is a rare and clinically more aggressive type of breast cancer. This type of breast cancer is called “inflammatory” because the breast often appears to be swollen, reddened, or “inflamed.” Some studies have demonstrated an association between familial history of breast cancer and IBC; however, additional studies are required to demonstrate this. IBC is classified as breast cancer at stage IIIB or IV. Some signaling pathways undoubtedly provide novel therapeutic targets for developing IBC inhibitors. By means of a cell line study, the loss has been identified of Wnt signaling pathway-induced protein 3 (WISP3/CCN6; LIBC [Lost in Inflammatory Breast Cancer]). Microarray analysis in IBC compared in noninflammatory tumors has demonstrated a signature of IBC that includes genes involved in IGF signaling, which we will discuss later in the section on microarrays and genomic signatures in IBC. Overexpression of epidermal growth factor receptors (ErbB) is very common in IBC. In another study, the expression and correlation was evaluated of the protein caveolin-1, which is a structural protein of the IBC-cell membrane caveolar microdomains (also described in breast cancer cell lines) and not in the cells of noninflammatory mammary cancer tumors. A protein that has demonstrated to possess tumor suppressor properties in breast cancer is E-cadherin; likewise, it has been demonstrated that it is found to be overexpressed in IBC, allowing the formation of lymphovascular emboli, which offers cytoprotector and resistance mechanisms to the chemotherapy of IBC cells. The genomic profile of IBC and of noninflammatory breast tumors stratified according to hormonal receptor state and HER2.

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Author information

Authors and Affiliations

  1. Laboratory of Translational Research in Cancer, Oncology Hospital, National Medical Center “Siglo XXI”, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtémoc 330, Col. Doctores, 06720, Mexico City, DF, Mexico

    Horacio Astudillo-de la Vega M.D., M.Sc., Ph.D

  2. Department of Medical Oncology, Instituto Nacional de Cancerología-México (INCan), Secretaría de Salud (Ssa), Mexico City, DF, Mexico

    Erika Ruiz-Garcia & Oscar Gerardo Arrieta-Rodriguez M.D.

  3. Department of Pathology, Instituto Nacional de Cancerologia-Mexico (INCan), Ssa, Mexico City, DF, Mexico

    Paula Juarez-Sanchez M.D.

  4. Department of Clinical Investigation, Instituto Nacional de Cancerologia-Mexico, Mexico City, DF, Mexico

    Jaime G. de la Garza-Salazar M.D.

Authors
  1. Horacio Astudillo-de la Vega M.D., M.Sc., Ph.D
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  2. Erika Ruiz-Garcia
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  3. Paula Juarez-Sanchez M.D.
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  4. Jaime G. de la Garza-Salazar M.D.
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  5. Oscar Gerardo Arrieta-Rodriguez M.D.
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Corresponding author

Correspondence to Horacio Astudillo-de la Vega M.D., M.Sc., Ph.D .

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Editors and Affiliations

  1. Instituto Nacional de Cancerología-Mexic, Ave San Fernando, Mexico City, 14080, Mexico

    Jaime G. de la Garza-Salazar

  2. Instituto Nacional de Cancerologia-Mexic, Ave San Fernando, Mexico City, 14080, Mexico

    Abelardo Meneses-Garcia

  3. Instituto Nacional de Cancerologia-Mexic, Ave San Fernando, Mexico City, 14080, Mexico

    Claudia Arce-Salinas

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Astudillo-de la Vega, H., Ruiz-Garcia, E., Juarez-Sanchez, P., de la Garza-Salazar, J.G., Arrieta-Rodriguez, O.G. (2013). The Molecular Biology of Inflammatory Breast Cancer. In: de la Garza-Salazar, J., Meneses-Garcia, A., Arce-Salinas, C. (eds) Inflammatory Breast Cancer. Springer, London. https://doi.org/10.1007/978-0-85729-991-8_9

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  • DOI: https://doi.org/10.1007/978-0-85729-991-8_9

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