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Radiotherapy in Inflammatory Breast Cancer

  • Diana Vanesa Toledano-Cuevas
  • Aida Mota-Garcia
  • Roque Alberto Guadarrama-Fleites
Chapter

Abstract

Inflammatory breast cancer (IBC) is an uncommon disease with a poor prognosis reported historically. The treatment of this disease has evolved significantly over the past decades, incorporating surgery, radiotherapy (RT), and chemotherapy (CT) for local and distant disease control.

The radiation provides excellent LRC and reasonable 5-year survival rates for patients with IBC who successfully complete the planned treatment course. Aggressive locoregional treatment strategies include hyperfractionated radiation therapy to the chest wall and draining lymph nodes at 51 Gy followed by a chest-wall boost dose at 66 Gy.

Keywords

Chest Wall Inflammatory Breast Cancer Internal Mammary Lymph Node Locally Advanced Breast Cancer Postmastectomy Radiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Bristol IJ, et al. Inflammatory breast cancer: current concepts in local management. Breast Dis. 2005;22:75–83.PubMedGoogle Scholar
  2. 2.
    Harris EE, et al. Ten-year outcome after combined modality therapy for inflammatory breast cancer. Int J Radiat Oncol Biol Phys. 2003;55(5):1200–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Liao Z, et al. Locoregional irradiation for inflammatory breast cancer: effectiveness of dose escalation in decreasing recurrence. Int J Radiat Oncol Biol Phys. 2000;47(5):1191–200.PubMedCrossRefGoogle Scholar
  4. 4.
    Fleming RY, Asmar L, Buzdar AU, et al. Effectiveness of mastectomy by response to induction chemotherapy for control in inflammatory breast carcinoma. Ann Surg Oncol. 1997;4:452–61.PubMedCrossRefGoogle Scholar
  5. 5.
    Barker JL, Nelson AJ, Montague ED. Inflammatory carcinoma of the breast. Radiology. 1976;121:173–6.PubMedGoogle Scholar
  6. 6.
    Panades M, Olivotto IA, Speers CH, et al. Evolving treatment strategies for inflammatory breast cancer: a population-based survival analysis. J Clin Oncol. 2005;23(9):1941–50.PubMedCrossRefGoogle Scholar
  7. 7.
    Ueno NT, Buzdar AU, Singletary SE, Ames FC, McNeese MD, Holmes FA, et al. Combined-modality treatment of inflammatory breast carcinoma: twenty years of experience at M.D. Anderson Cancer Center. Cancer Chemother Pharmacol. 1997;40(4):321–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Rousse J, Friedman S, Sarrazin D, et al. Primary chemotherapy in treatment of inflammatory breast carcinoma: a study of 230 cases for the Institut Gustave-Roussy. J Clin Oncol. 1986;4:1765–71.Google Scholar
  9. 9.
    Thoms Jr WW, et al. Multimodal treatment for inflammatory breast cancer. Int J Radiat Oncol Biol Phys. 1998;17:739–45.CrossRefGoogle Scholar
  10. 10.
    Mourali N, Tabbane F, Muenz LR, Behi J, Ben Moussa F, Jaziri M, et al. Ten-year results utilizing chemotherapy as primary treatment in nonmetastatic, rapidly progressing breast cancer. Cancer Invest. 1993;11(4):363–70.PubMedCrossRefGoogle Scholar
  11. 11.
    De Boer RH, Allum WH, Ebbs S, et al. Multimodality therapy in inflammatory breast cancer: is there a place for surgery? Ann Oncol. 2000;11:1147–53.PubMedCrossRefGoogle Scholar
  12. 12.
    Fleming RY. Effectiveness of mastectomy by response to induction chemotherapy for control in inflammatory breast carcinoma. Ann Surg Oncol. 1997;4(6):452–61.PubMedCrossRefGoogle Scholar
  13. 13.
    Dawood S, Cristofanilli M. Oncology inflammatory breast cancer: what progress have we made? Oncology (Williston Park). 2011;25(3):264–70.Google Scholar
  14. 14.
    Pisansky TM, et al. Inflammatory breast cancer: integration of irradiation, surgery, and chemotherapy. Am J Clin Oncol. 1992;15(5):376–87.PubMedCrossRefGoogle Scholar
  15. 15.
    Chu AM, Wood WC, Doucette JA. Inflammatory breast carcinoma treated by radical radiotherapy. Cancer. 1980;45:2730–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Pérez CA, Fields JN, Fracasso PM, et al. Management of locally advanced carcinoma of the breast. II: inflammatory carcinoma. Cancer. 1994;74(1 Suppl):466–76.PubMedCrossRefGoogle Scholar
  17. 17.
    Rouesse J, Friedman S, Sarrazin D, et al. Primary chemotherapy in the treatment of inflammatory breast carcinoma: a study of 230 cases for the Institut Gustave-Roussy. J Clin Oncol. 1986;4:1765–71.PubMedGoogle Scholar
  18. 18.
    Liauw SL, et al. Inflammatory breast carcinoma: outcomes with trimodality therapy for nonmetastatic disease. Cancer. 2004;100(5):920–8.PubMedCrossRefGoogle Scholar
  19. 19.
    Thames Jr HD, et al. Accelerated fractionation vs. hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys. 1983;9(2):127–38.PubMedCrossRefGoogle Scholar
  20. 20.
    Cox JD. Chemoradiation for malignant epithelial tumors. Cancer Radiother. 1998;2(1):7–11.PubMedCrossRefGoogle Scholar
  21. 21.
    Genet D, et al. Concomitant intensive chemoradiotherapy induction in non-metastatic inflammatory breast cancer: long-term follow-up. Br J Cancer. 2007;97(7):883–7.PubMedGoogle Scholar
  22. 22.
    Hasbini A, Le Pechoux C, Roche B, et al. Alternating chemotherapy and hyperfractionated accelerated radiotherapy in non-metatastic inflammatory breast cancer. Cancer Radiother. 2000;4:265–73.PubMedCrossRefGoogle Scholar
  23. 23.
    Barker JL, Montague ED, et al. Clinical experience with irradiation of inflammatory carcinoma of the breast with and without elective chemotherapy. Cancer. 1980;45:625–9.PubMedCrossRefGoogle Scholar
  24. 24.
    Arthur DW, et al. Accelerated superfractionated radiotherapy for inflammatory breast carcinoma: complete response predicts outcome and allows for breast conservation. Int J Radiat Oncol Biol Phys. 1999;44(2):289–96.PubMedCrossRefGoogle Scholar
  25. 25.
    Bristol IJ, et al. Locoregional treatment outcomes after multimodality management of inflammatory breast cancer. Int J Radiat Oncol Biol Phys. 2008;72(2):474–84.PubMedCrossRefGoogle Scholar
  26. 26.
    Woodward WA, et al. The role of locoregional therapy in inflammatory breast cancer. Semin Oncol. 2008;35(1):78–86.PubMedCrossRefGoogle Scholar
  27. 27.
    Walker GV, et al. Pretreatment staging positron emission tomography/computed tomography inpatients with inflammatory breast cancer influences radiation treatment field designs. Int J Radiat Oncol Biol Phys. 2012;8(1):1381–86.Google Scholar
  28. 28.
    Alberini JL, et al. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging in the staging and prognosis of inflammatory breast cancer. Cancer. 2009;115(21):5038–47.PubMedCrossRefGoogle Scholar
  29. 29.
    Kuske RR, et al. Diagnosis and management of inflammatory breast cancer. Sem Radiat Oncol. 1994;4:270–82.CrossRefGoogle Scholar
  30. 30.
    Marks LB, et al. To treat or not to treat the internal mammary nodes. Int J Radiat Oncol Biol Phys. 1994;29:903–9.PubMedCrossRefGoogle Scholar
  31. 31.
    Siddon SL, et al. Three-field technique for breast irradiation using tangential field corner blocks. Int J Radiat Oncol Biol Phys. 1983;9:583–8.PubMedCrossRefGoogle Scholar
  32. 32.
    Pierce LJ, et al. Postmastectomy radiotherapy of the chest wall: dosimetric comparison of common techniques. Int J Radiat Oncol Biol Phys. 2002;52(5):1220–30.PubMedCrossRefGoogle Scholar
  33. 33.
    Chu JC, Solin LJ, Hwang CC, et al. A non-divergent three field matching technique for breast irradiation. Int J Radiat Oncol Biol Phys. 1990;19:1037–40.PubMedCrossRefGoogle Scholar
  34. 34.
    International Commission on Radiation Units and Measurements (ICRU). Prescribing, recording and reporting photon beam therapy (supplement to ICRU report 50), Bethesda, 1999.Google Scholar
  35. 35.
    Landis DM, Luo W, Son J, et al. Variability among breast radiation oncologist in delineation of postsurgical lumpectomy cavity. Int J Radiat Oncol Biol Phys. 2007;67:1299–308.PubMedCrossRefGoogle Scholar
  36. 36.
    Damast S, et al. Locoregional outcomes of inflammatory breast cancer patients treated with standard fractionation radiation and daily skin bolus in the taxane era. Int J Radiat Oncol Biol Phys. 2010;77(4):1105–12.PubMedCrossRefGoogle Scholar
  37. 37.
    Emamin B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 1991;21:109–22.CrossRefGoogle Scholar
  38. 38.
    Gagliardi G, Lax I, Rutqvist LE. Partial irradiation of the heart. Semin Radiat Oncol. 2000;11:224–5.CrossRefGoogle Scholar
  39. 39.
    Hurkmans CW, Borger JH, et al. Cardiac and lung complication probabilities after breast cancer irradiation. Radiother Oncol. 2000;55:145–51.PubMedCrossRefGoogle Scholar
  40. 40.
    Muren LP, Maurstad G, Hafslund R, et al. Cardiac and pulmonary doses and complication probabilities in standard and conformal tangential irradiation in conservative management of breast cancer. Radiother Oncol. 2002;62:173–83.PubMedCrossRefGoogle Scholar
  41. 41.
    Jones J, Ribeiro G. Mortality patterns over 34 years of breast cancer patients in a clinical trial of post-operative radiotherapy. Clin Radiol. 1989;40:204–8.PubMedCrossRefGoogle Scholar
  42. 42.
    Haybittle JL, Brinkley D, Houghton J, et al. Postoperative radiotherapy and late mortality: evidence from the cancer research campaign trial for early breast cancer. BMJ. 1989;298:1611–4.PubMedCrossRefGoogle Scholar
  43. 43.
    Fuller SA, Haybittle JL, Smith RE, et al. Cardiac doses in post-operative breast irradiation. Radiother Oncol. 1992;25:19–24.PubMedCrossRefGoogle Scholar
  44. 44.
    Hurkmans CW, Cho BC, Damen E, et al. Reduction of cardiac and lung complication probabilities after breast irradiation using conformal radiotherapy with or without intensity modulation. Radiother Oncol. 2002;62:163–71.PubMedCrossRefGoogle Scholar
  45. 45.
    Hojris I, Overgaard M, Christensen JJ, et al. Morbidity and mortality of ischemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomized trials. Lancet. 1999;354:1425–30.PubMedCrossRefGoogle Scholar
  46. 46.
    Moran MS, Haffty BG. Radiation techniques and toxicities for local advanced breast cancer. Semin Radiat Oncol. 2009;19:244–55. Lu HM, Cash E, Chen MH, et al. Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: a CT study. Int J Radiat Oncol Biol Phys. 2000;47:895–904.Google Scholar
  47. 47.
    Korreman SS, Pedersen AN, Nottrup TJ, et al. Breathing adapted radiotherapy for breast cancer: comparison of free breathing gating with the breath-hold technique. Radiother Oncol. 2005;76:311–8.PubMedCrossRefGoogle Scholar
  48. 48.
    Remouchamps VM, Vicini FA, Sharpe MB, et al. Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation. Int J Radiat Oncol Biol Phys. 2003;55:392–406.PubMedCrossRefGoogle Scholar
  49. 49.
    Canney PA, Deehan C, Glegg M, et al. Reducing cardiac dose in post-operative irradiation of breast cancer patients: the relative importance of patient positioning and CT scan planning. Br J Radiol. 1999;72:986–93.PubMedGoogle Scholar
  50. 50.
    Gyenes G, Gagliardi G, Lax I, et al. Evaluation of irradiated heart volumes in stage I breast cancer patients treated with postoperative adjuvant radiotherapy. J Clin Oncol. 1997;15:1348–53.PubMedGoogle Scholar
  51. 51.
    Kimsey FC, Mendenhall NP, Ewald LM, et al. Is radiation treatment volume a predictor for acute or late effects on pulmonary function? A prospective study of patients treated with breast-conserving surgery and post-operative irradiation. Cancer. 1994;73:2549–55.PubMedCrossRefGoogle Scholar
  52. 52.
    Lind P, Wennberg B, Gagliardi G, et al. Pulmonary complications following different radiotherapy techniques for breast cancer, and the association to irradiated lung volume and dose. Breast Cancer Res Treat. 2001;68:199–210.PubMedCrossRefGoogle Scholar
  53. 53.
    Krengli M, Sacco M, Loi G, et al. Pulmonary changes after radiotherapy for conservative treatment of breast cancer: a prospective study. Int J Radiat Oncol Biol Phys. 2008;70:1460–7.PubMedCrossRefGoogle Scholar
  54. 54.
    Svensson H, Westling P, Larsson L-G. Radiation-induced lesions of the brachial plexus correlated to the dose-time-fractionation schedule. Acta Radiol Ther Phys Biol. 1975;14:228–38.PubMedGoogle Scholar
  55. 55.
    Rubin D, Schomberg P, Shepard R, et al. Arteritis and brachial plexus neuropathy as delayed complications of radiation therapy. Mayo Clin Proc. 2001;76(8):849–52.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Diana Vanesa Toledano-Cuevas
    • 1
  • Aida Mota-Garcia
    • 1
  • Roque Alberto Guadarrama-Fleites
    • 1
  1. 1.Department of Radiation OncologyInstituto Nacional de Cancerologia-MexicoTlalpan, Mexico CityMexico

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