Inflammatory Breast Cancer: Clinical Presentation, Diagnosis, Staging Evaluation, Differential Diagnosis, Surgical Treatment, and Follow-Up

  • Juan Enrique Bargallo-RochaEmail author
  • Robin J. Shaw-Dulin
  • Teresa Ramirez-Ugalde
  • Angel Herrera-Gomez


Inflammatory breast cancer is a rare and aggressive form of breast cancer with a relatively poor prognosis and is characterized by a rapid onset of classic clinical and pathologic features, rapid progression, and early metastases. Several conditions may be confused with IBC, leading to delays in diagnosis and treatment. Current management of inflammatory cancer is based on multidisciplinary treatment including neoadjuvant chemotherapy and subsequent locoregional treatment including surgery and radiation therapy. Mastectomy has been proven to be an integral part of combination treatment, contributing to local control and improved survival.


Sentinel Lymph Node Biopsy Core Needle Biopsy Inflammatory Breast Cancer Locally Advanced Breast Cancer Breast Abscess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Edge SB, Byrd DR, Compton CC, et al., editors. AJCC (American Joint Committee on Cancer) cancer staging manual. 7th ed. New York: Springer; 2010.Google Scholar
  2. 2.
    Hance KW, Anderson WF, Devesa SS, et al. Trends in inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program at the National Cancer Institute. J Natl Cancer Inst. 2005;97:966.PubMedCrossRefGoogle Scholar
  3. 3.
    Anderson WF, Schairer C, Chen BE, et al. Epidemiology of inflammatory breast cancer (IBC). Breast Dis. 2005–2006;22:9.Google Scholar
  4. 4.
    Tai P, Yu E, Shiels R, et al. Short- and long-term cause-specific survival of patients with inflammatory breast cancer. BMC Cancer. 2005;5:137.PubMedCrossRefGoogle Scholar
  5. 5.
    Kleer CG, van Golen KL, Merajver SD. Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants. Breast Cancer Res. 2000;2:423.PubMedCrossRefGoogle Scholar
  6. 6.
    Jaiyesimi IA, Buzdar AU, Hortobagyi G. Inflammatory breast cancer: a review. J Clin Oncol. 1992;10:1014.PubMedGoogle Scholar
  7. 7.
    Walshe JM, Swain SM. Clinical aspects of inflammatory breast cancer. Breast Dis. 2005–2006;22:35.Google Scholar
  8. 8.
    Smoot RL, Koch CA, Degnim AC, et al. A single-center experience with inflammatory breast cancer, 1985–2003. Arch Surg. 2006;141:567.PubMedCrossRefGoogle Scholar
  9. 9.
    Chow CK. Imaging in inflammatory breast carcinoma. Breast Dis. 2005–2006;22:45.Google Scholar
  10. 10.
    Pérez CA, Fields JN, Fracasso PM, et al. Management of locally advanced carcinoma of the breast. II. Inflammatory carcinoma. Cancer. 1994;74:466.PubMedCrossRefGoogle Scholar
  11. 11.
    Thoms Jr WW, McNeese MD, Fletcher GH, et al. Multimodal treatment for inflammatory breast cancer. Int J Radiat Oncol Biol Phys. 1989;17:739.PubMedCrossRefGoogle Scholar
  12. 12.
    Baldini E, Gardin G, Evagelista G, et al. Long-term results of combined-modality therapy for inflammatory breast carcinoma. Clin Breast Cancer. 2004;5:358.PubMedCrossRefGoogle Scholar
  13. 13.
    Liauw SL, Benda RK, Morris CG, Mendenhall NP. Inflammatory breast carcinoma: outcomes with trimodality therapy for nonmetastatic disease. Cancer. 2004;100:920.PubMedCrossRefGoogle Scholar
  14. 14.
    Harris EE, Schultz D, Bertsch H, et al. Ten-year outcome after combined modality therapy for inflammatory breast cancer. Int J Radiat Oncol Biol Phys. 2003;55:1200.PubMedCrossRefGoogle Scholar
  15. 15.
    Palangie T, Mosseri V, Mihura J, et al. Prognostic factors in inflammatory breast cancer and therapeutic implications. Eur J Cancer. 1994;30A:921.PubMedCrossRefGoogle Scholar
  16. 16.
    Hennessy BT, González-Angulo AM, Hortobagyi GN, et al. Disease-free and overall survival after pathologic complete disease remission of cytologically proven inflammatory breast carcinoma axillary lymph node metastases after primary systemic chemotherapy. Cancer. 2006;106:1000.PubMedCrossRefGoogle Scholar
  17. 17.
    Harris J., Lippman M., Morrow M., Osborne C. Diseases of the Breast 4th Edition. 2009.PubMedCrossRefGoogle Scholar
  18. 18.
    Cristofanilli M, Buzdar AU, Hortobágyi GN. Update on the management of inflammatory breast cancer. Oncologist. 2003;8:141.PubMedCrossRefGoogle Scholar
  19. 19.
    Liao Z, Strom EA, Buzdar AU, et al. Locoregional irradiation for inflammatory breast cancer: effectiveness of dose escalation in decreasing recurrence. Int J Radiat Oncol Biol Phys. 2000;47:1191.PubMedCrossRefGoogle Scholar
  20. 20.
    De Boer RH, Allum WH, Ebbs SR, et al. Multimodality therapy in inflammatory breast cancer: is there a place for surgery? Ann Oncol. 2000;11:1147.PubMedCrossRefGoogle Scholar
  21. 21.
    Brun B, Otmezguine Y, Feuilhade F, et al. Treatment of inflammatory breast cancer with combination chemotherapy and mastectomy versus breast conservation. Cancer. 1988;61:1096.PubMedCrossRefGoogle Scholar
  22. 22.
    Bristol IJ, Buchholz TA. Inflammatory breast cancer: current concepts in local management. Breast Dis. 2005–2006;22:75.Google Scholar
  23. 23.
    Panades M, Olivotto IA, Speers CH, et al. Evolving treatment strategies for inflammatory breast cancer: a population-based survival analysis. J Clin Oncol. 2005;23:1941.PubMedCrossRefGoogle Scholar
  24. 24.
    Curcio LD, Rupp E, Williams WL, et al. Beyond palliative mastectomy in inflammatory breast cancer – a reassessment of margin status. Ann Surg Oncol. 1999;6:249.PubMedCrossRefGoogle Scholar
  25. 25.
    Pisansky TM, Schaid DJ, Loprinzi CL, et al. Inflammatory breast cancer: integration of irradiation, surgery, and chemotherapy. Am J Clin Oncol. 1992;15:376.PubMedCrossRefGoogle Scholar
  26. 26.
    TREVES N. The inoperability of inflammatory carcinoma of the breast. Surg Gynecol Obstet. 1959 Aug; 109 (2):240–242.PubMedCrossRefGoogle Scholar
  27. 27.
    Cristofanilli M, Valero V, Buzdar AU, et al. Inflam­matory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique disease. Cancer. 2007;110:1436.PubMedCrossRefGoogle Scholar
  28. 28.
    Talwalkar SS, Miranda RN, Valbuena JR, et al. Lymphomas involving the breast: a study of 106 cases comparing localized and disseminated neoplasms. Am J Surg Pathol. 2008;32:1299.PubMedCrossRefGoogle Scholar
  29. 29.
    Wong WW, Schild SE, Halyard MY, Schomberg PJ. Primary non-Hodgkin lymphoma of the breast: the mayo clinic experience. J Surg Oncol. 2002;80:19.PubMedCrossRefGoogle Scholar
  30. 30.
    Kamal RM, Hamed ST, Salem DS. Classification of inflammatory breast disorders and step by step diagnosis. Breast J. 2009;15:367.PubMedCrossRefGoogle Scholar
  31. 31.
    Baharoon S. Tuberculosis of the breast. Ann Thorac Med. 2008;3:110.PubMedCrossRefGoogle Scholar
  32. 32.
    De la Garza-Salazar, JG, et al. Different management of inflammatory breast cancer. In: American Society of clinical oncology (meeting), Abstract C-32, Denver, 1977.Google Scholar
  33. 33.
    De la Garza J, et al. Cancer inflamatorio de la glándula mamaria. Experiencia de 6 años con Qt. Rt. Cir Ciruj (Mexico) 1977;45(6):351–7.Google Scholar
  34. 34.
    Kell MR, Marrow M. Surgical aspects of inflammatory breast cancer. Breast Dis. 2005–2006;22:67–73.Google Scholar
  35. 35.
    Haagensen CD (1971) Diseases of the Breast 2nd edn, Philadelphia: WB Saunders Company.Google Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Juan Enrique Bargallo-Rocha
    • 1
    Email author
  • Robin J. Shaw-Dulin
    • 2
  • Teresa Ramirez-Ugalde
    • 2
  • Angel Herrera-Gomez
    • 3
  1. 1.Department of Breast CancerInstituto Nacional de Cancerologia-MexicoTlalpan, Mexico CityMexico
  2. 2.Department of Breast TumorsInstituto Nacional de Cancerologia-MexicoMexico CityMexico
  3. 3.Department of Surgical OncologyInstituto Nacional de Cancerologia-MexicoMexico CityMexico

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