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Target Therapy in Inflammatory Breast Cancer

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Inflammatory Breast Cancer

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Abstract

Systemic treatment with chemotherapy (CT) and other target therapies is the cornerstone in the treatment of the inflammatory breast cancer (IBC). Completeness a distinctive biological characterize and separate IBC from noninflammatory breast cancer.

These are characteristics that are associated with poor prognosis and include a high S-phase fraction, high grade, aneuploidy, loss of hormonal receptors, and overexpression of human epithelial receptor-2 (HER2), p-53-level mutations. IBC overexpresses E-cadherin, a calcium-regulating transmembrane glycoprotein that promotes cell-cell adhesion, and through this, promotes invasion with tumor emboli of the dermal lymphatic system. Dysregulation of p27kip1, a cyclin-dependent kinase (CDK), and high endothelial-cell proliferation, and the expression of lymphangiogenetic factors (VEGF-C, VEGF-D, VEGFR-3, Prox-1), and the lymphatic vascular endothelial receptor 1 and angiogenic factors (Basic fibroblast growth factor [bFGF], Vascular endothelial growth factor [VEGF], Interleukin-6 [IL-6], and IL-8).

The advent of new biological treatments has represented an additional benefit because the percentages of pathological response (PR) have improved, and there is even better prognosis.

At present, the target therapy is a new therapeutic resource, and progress is being made toward new horizons in the management of inflammatory breast cancer (IBC).

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Authors and Affiliations

  1. Department of Medical Oncology, Instituto Nacional de Cancerologia-Mexico, San Fernando Num 22, Tlalpan, Mexico City, DF, 14080, Mexico

    Flavia Morales-Vasquez M.D., M.S., Claudia Arce-Salinas M.D., M.S. & Jose Luis Aguilar-Ponce M.D.

  2. Department of Oncological Surgery, Instituto Nacional de Cancerologia-Mexico, Mexico City, DF, Mexico

    Horacio Noe Lopez-Basave M.S.

  3. Department of Medical Oncology, Instituto Nacional de Cancerologia-Mexico, Mexico City, DF, Mexico

    Oscar Gerardo Arrieta-Rodriguez M.D.

Authors
  1. Flavia Morales-Vasquez M.D., M.S.
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  2. Horacio Noe Lopez-Basave M.S.
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  3. Claudia Arce-Salinas M.D., M.S.
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  4. Jose Luis Aguilar-Ponce M.D.
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Correspondence to Flavia Morales-Vasquez M.D., M.S. .

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Editors and Affiliations

  1. Instituto Nacional de Cancerología-Mexic, Ave San Fernando, Mexico City, 14080, Mexico

    Jaime G. de la Garza-Salazar

  2. Instituto Nacional de Cancerologia-Mexic, Ave San Fernando, Mexico City, 14080, Mexico

    Abelardo Meneses-Garcia

  3. Instituto Nacional de Cancerologia-Mexic, Ave San Fernando, Mexico City, 14080, Mexico

    Claudia Arce-Salinas

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Morales-Vasquez, F., Lopez-Basave, H.N., Arce-Salinas, C., Aguilar-Ponce, J.L., Arrieta-Rodriguez, O.G. (2013). Target Therapy in Inflammatory Breast Cancer. In: de la Garza-Salazar, J., Meneses-Garcia, A., Arce-Salinas, C. (eds) Inflammatory Breast Cancer. Springer, London. https://doi.org/10.1007/978-0-85729-991-8_10

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  • DOI: https://doi.org/10.1007/978-0-85729-991-8_10

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