Antibodies to Proteus in Rheumatoid Arthritis Patients from Brest and Toulouse in France

  • Alan Ebringer


In the early 1990s, Professor Pierre Youinou from the University of Brest in France carried out collaborative studies on lymphocytes with Professor Ivan Roitt, in the Department of Immunology at the Middlesex Hospital in London. He came to know the work being carried out by the King’s College Immunology group on Proteus antibodies in English patients and asked whether this was a general observation which applied to rheumatoid arthritis patients in different countries. He was interested in the question if similar observations could be made on French patients suffering from rheumatoid arthritis. He said that he could obtain sera from rheumatoid arthritis patients in Brest and also from a colleague Dr. A. Cantagrel in Toulouse, in south-western France and would provide control sera from the Blood Bank in Brest. However, he insisted that he would code the sera himself in France before they were dispatched to the UK. The studies would be carried out in London, results then sent back to France, decoded and the appropriate calculations carried out.


Rheumatoid Arthritis Rheumatoid Arthritis Patient Proteus Mirabilis Rheumatoid Arthritis Group French Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Fielder M, Youinou P, Cantagrel A, Wilson C, Ebringer A. Elevation of anti-Proteus antibody titres in rheumatoid arthritis patients from Brest and Toulouse measured by immunofluorescence: a coded study. Clin Exp Rheumatol. 1994;12(Suppl II):S104, Abst C125.Google Scholar
  2. Fielder M, Tiwana H, Youinou P, Le Goff P, Deonarain R, Wilson C, et al. The specificity of the of anti-Proteus antibody response in tissue typed rheumatoid arthritis patients from Brest. Rheumatol Int. 1995;15:79–82.PubMedCrossRefGoogle Scholar
  3. Mancini G, Carbonara HO, Heremans JF. Immunological quantification of antigens by single radial immunodiffusion. Immunochemistry. 1965;2:235–53.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Alan Ebringer
    • 1
  1. 1.King’s College London Division of Life SciencesUCH School of MedicineLondonUK

Personalised recommendations