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Rheumatoid Arthritis Sera Are Cytotoxic to Cells Bearing HLA and Collagen Susceptibility Sequences

  • Alan Ebringer
Chapter

Abstract

The HLA-DR alleles, DRB1*0401, *0402, *0405, *0101 and *1402, which share an amino acid sequence EQR(K)RAA in the DRB1 chain, have been linked with a susceptibility to develop rheumatoid arthritis.

It has been suggested that an environmental factor interacting with a genetic predisposition contributes to the pathogenesis of rheumatoid arthritis.

Keywords

Rheumatoid Arthritis Rheumatoid Arthritis Patient Klebsiella Pneumoniae Proteus Mirabilis Healthy Blood Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Alan Ebringer
    • 1
  1. 1.King’s College London Division of Life SciencesUCH School of MedicineLondonUK

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