Rheumatoid Arthritis Sera Are Cytotoxic to Cells Bearing HLA and Collagen Susceptibility Sequences

  • Alan Ebringer


The HLA-DR alleles, DRB1*0401, *0402, *0405, *0101 and *1402, which share an amino acid sequence EQR(K)RAA in the DRB1 chain, have been linked with a susceptibility to develop rheumatoid arthritis.

It has been suggested that an environmental factor interacting with a genetic predisposition contributes to the pathogenesis of rheumatoid arthritis.


Rheumatoid Arthritis Rheumatoid Arthritis Patient Klebsiella Pneumoniae Proteus Mirabilis Healthy Blood Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Boissier MC, Chiochia G, Ronzière MC, Herbage D, Fournier C. Arthritogenicity of minor collagens (types IX and XI) in mice. Arthritis Rheum. 1990;33:1–9.PubMedCrossRefGoogle Scholar
  2. Cunningham MW, Antone SM, Gulizia JM, McManus BM, Fischetti VA, Gaunt CJ. Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses and human cardiac myosin. Proc Natl Acad Sci USA. 1992;89:1320–4.PubMedCrossRefGoogle Scholar
  3. Dybwad A, Forre O, Siuod M. Increased serum and synovial antibodies to immunoselected peptides in patients with rheumatoid arthritis. Ann Rheum Dis. 1996;55:437–41.Google Scholar
  4. Fielder M, Pirt SJ, Tarpey I, Wilson C, Cunningham P, Ettelaie C, et al. Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae. FEBS Lett. 1995;369:243–8.PubMedCrossRefGoogle Scholar
  5. Mobley LTH, Chippendale GR, Swihart KG, Welch RA. Cytotoxicity of the Hpm A haemolysin and urease of Proteus mirabilis, Proteus vulgarisagainst cultured renal proximal tubular epithelial cells. Infect Immun. 1991;59:2036–42.PubMedGoogle Scholar
  6. Morgan K, Clague RB, Collins I, Ayad S, Phinn SD, Holt PJL. Incidence of antibodies to native and denatured cartilage collagens (types II, IX and XI) and type I collagen in rheumatoid arthritis. Ann Rheum Dis. 1987;46:902–7.PubMedCrossRefGoogle Scholar
  7. Musher DM, Griffith DP, Yawn D, Rossen RD. The role of urease in pyelonephritis resulting in urinary tract infection with Proteus. J Infect Dis. 1975;31:177–81.CrossRefGoogle Scholar
  8. Newkirk MM, Goldbach-Mansky R, Senior BW, Klippel J, Schumacher HR, El-Gabalawy HS. Elevated levels of IgA and IgM antibodies to Proteus mirabilisand IgM antibodies to Escherichia coliare associated with early rheumatoid factor (RF) positive rheumatoid arthritis. Rheumatology (Oxford). 2005;44:1433–41.CrossRefGoogle Scholar
  9. Peerbooms PGH, Marian A, Verweij JJ, MacLaren DM. Vero cell invasiveness of Proteus mirabilis. Infect Immun. 1984;43:1068–71.PubMedGoogle Scholar
  10. Senior BW, McBride RDP, Morley KD, Kerr MA. The detection of raised levels of IgM to Proteus mirabilisin sera from patients with rheumatoid arthritis. J Med Microbiol. 1995;43:176–84.PubMedCrossRefGoogle Scholar
  11. Takeuchi F, Kosuge E, Matsuta K, Nakano K, Tokunaga K, Juji T et al. Antibody to a specific HLA-DRβ1 sequence in Japanese patients with rheumatoid arthritis. Arthritis Rheum. 1990;33: 1867–8.Google Scholar
  12. Wilson C, Rashid T, Tiwana H, Beyan H, Hughes L, Bansal S, et al. Cytotoxicity responses to peptide antigens in rheumatoid arthritis and ankylosing spondylitis. J Rheumatol. 2003;30:972–8.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Alan Ebringer
    • 1
  1. 1.King’s College London Division of Life SciencesUCH School of MedicineLondonUK

Personalised recommendations