Rheumatoid Arthritis Sera Are Cytotoxic to Cells Bearing HLA and Collagen Susceptibility Sequences
The HLA-DR alleles, DRB1*0401, *0402, *0405, *0101 and *1402, which share an amino acid sequence EQR(K)RAA in the DRB1 chain, have been linked with a susceptibility to develop rheumatoid arthritis.
It has been suggested that an environmental factor interacting with a genetic predisposition contributes to the pathogenesis of rheumatoid arthritis.
KeywordsRheumatoid Arthritis Rheumatoid Arthritis Patient Klebsiella Pneumoniae Proteus Mirabilis Healthy Blood Donor
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