The HLA-DR alleles, DRB1*0401, *0402, *0405, *0101 and *1402, which share an amino acid sequence EQR(K)RAA in the DRB1 chain, have been linked with a susceptibility to develop rheumatoid arthritis.
It has been suggested that an environmental factor interacting with a genetic predisposition contributes to the pathogenesis of rheumatoid arthritis and studies from our group have suggested that antigens present in the urinary microbe Proteus mirabilis are somehow involved in the pathology of this disease.
Rheumatoid Arthritis Optical Density Unit Proteus Mirabilis Untransfected Cell Rheumatoid Arthritis Susceptibility
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Barber LD, Bal V, Lamb JR, O’Hehir J, Yendle J, Hancock RJT, et al. Contribution of T-cell receptor contacting and peptide binding residues of the class II molecules of HLA-DR4.Dw10 to serologic and antigen specific T-cell recognition. Hum Immunol. 1991;32:110–8.PubMedCrossRefGoogle Scholar
Green N, Alexander H, Olson A, Alexander S, Shinnick TM, Sutcliffe JG, et al. Immunogenic structure of the influenza virus haemagglutinin. Cell. 1982;28:477–87.PubMedCrossRefGoogle Scholar
Hammer J, Gallazzi F, Bono E, Karr RW, Guenot J, Valsasnini P, et al. Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J Exp Med. 1995;181:1847–55.PubMedCrossRefGoogle Scholar
Kaiser E, Bossinger CD, Colescott RL, Olsen DB. Colour test for terminal proline residues in solid phase synthesis of peptides. Ann Chem Acta. 1980;118:149–51.CrossRefGoogle Scholar
Tiwana H, Wilson C, Alvarez A, Abuknesha R, Bansal S, Ebringer A. Cross-reactivity between the rheumatoid arthritis associated motif EQKRAA and structurally related sequences found in Proteus mirabilis. Infect Immun. 1999;67:2769–75.PubMedGoogle Scholar
Wilson C, Tiwana H, Ebringer A. Molecular mimicry between HLA-DR alleles associated with rheumatoid arthritis and Proteus mirabilis as the aetiological basis for autoimmunity. Microbes Infect. 2000;2:1489–96.PubMedCrossRefGoogle Scholar