Molecular Similarity Between the Rheumatoid Arthritis Associated Motif EQKRAA and Structurally Related Sequences of Proteus

  • Alan Ebringer


The HLA-DR alleles, DRB1*0401, *0402, *0405, *0101 and *1402, which share an amino acid sequence EQR(K)RAA in the DRB1 chain, have been linked with a susceptibility to develop rheumatoid arthritis.

It has been suggested that an environmental factor interacting with a genetic predisposition contributes to the pathogenesis of rheumatoid arthritis and studies from our group have suggested that antigens present in the urinary microbe Proteus mirabilis are somehow involved in the pathology of this disease.


Rheumatoid Arthritis Optical Density Unit Proteus Mirabilis Untransfected Cell Rheumatoid Arthritis Susceptibility 
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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Alan Ebringer
    • 1
  1. 1.King’s College London Division of Life SciencesUCH School of MedicineLondonUK

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