Gram-Negative Bacteria Possess Sequences Which Resemble the ‘Shared Epitope’ but Only Proteus Infect Rheumatoid Arthritis Patients

  • Alan Ebringer


The ‘shared epitope’ EQRRAA has been found to resemble or show ‘molecular mimicry’ with the sequence ESRRAL spanning residues 32–37 of the surface membrane haemolysin of Proteus mirabilis (Hpm B polypeptide).

The same hexamer sequence was also found in the membrane haemolysin of Serratia marcescens (Shl B polypeptide).


Rheumatoid Arthritis Rheumatoid Arthritis Patient Pseudomonas Aeruginosa Healthy Control Subject Rheumatic Fever 
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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Alan Ebringer
    • 1
  1. 1.King’s College London Division of Life SciencesUCH School of MedicineLondonUK

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