The ‘Shared Epitope’, Proteus Haemolysin, Type XI Collagen and Rheumatoid Arthritis

  • Alan Ebringer


The association between rheumatoid arthritis and some subtypes of HLA-DR4 is well known and a particular region of the DRβ1 chain, from positions 70–74 coding for amino acids Gln-Arg-Arg-Ala-Ala (QRRAA) and found in DRB1*0101 (DR1) and some DR4 subtypes DRB1*0404 (DW14) and DRB1*0405 (Dw15), has been identified as the molecular sequence responsible for the susceptibility to rheumatoid arthritis (Nepom et al. 1989).


Rheumatoid Arthritis Rheumatoid Arthritis Patient Healthy Control Subject Hyaline Cartilage Proteus Mirabilis 
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© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Alan Ebringer
    • 1
  1. 1.King’s College London Division of Life SciencesUCH School of MedicineLondonUK

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