Molecular Similarity Between the ‘Shared Epitope’ of Rheumatoid Arthritis and Bacteria
The association between rheumatoid arthritis and some subtypes of HLA-DR4 is well established not only in white subjects but also in many other ethnic groups. HLA-DR4 can be subdivided into several subtypes, only some of which are associated with rheumatoid arthritis (Stastny 1978).
KeywordsRheumatoid Arthritis Glutamic Acid Serratia Marcescens Charged Amino Acid Proteus Mirabilis
- Chou PY, Fasman G. Prediction of the secondary structure of proteins from the amino acid sequence. Adv Enzymol. 1978;47:145–7.Google Scholar
- Uphoff TS, Welch RA. Nucleotide sequencing of the Proteus mirabilis calcium independent haemolysin genes (hpm A and hpm B) reveals sequence similarity with the Serratia marcescens haemolysin genes (shl A and shl B). J Bacteriol. 1990;170:3177–88.Google Scholar