B-Cell-Targeted Therapies in Sjögren’s Syndrome

  • Xavier Mariette


B-cell hyperactivity has been recognized for a long time in Sjögren’s syndrome (SS). More than 30 years ago, Talal et al. demonstrated an increased level of beta-2-microglobulin in the serum of patients with SS [1]. More than 20 years ago, Moutsopoulos et al. detected increased levels of immunoglobulin light chains within the sera of patients with SS [2].


Systemic Lupus Erythematosus Progressive Multifocal Leukoencephalopathy Progressive Multifocal Leukoencephalopathy Immunoglobulin Light Chain Rheumatoid Factor Level 


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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Xavier Mariette
    • 1
    • 2
  1. 1.Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP)Université Paris-Sud 11Le Kremlin BicêtreFrance
  2. 2.Institut Pour la Santé et la Recherche Médicale (INSERM)ParisFrance

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