Primary Sjögren’s Syndrome and Viruses

  • Manuel Ramos-Casals
  • Albert Bové
  • Rafael Belenguer
  • Xavier Forns
  • Salvatore de Vita


The etiopathogenesis of primary Sjögren’s syndrome (SS) is probably a sequential, multistep process that leads to selective damage of the exocrine glands and consequent target organ dysfunction. Although understanding of the precise mechanisms involved in etiopathogenesis of SS remains incomplete, the autoimmune origin of the disease (autoimmune epithelitis) [1] is the hypothesis postulated most commonly.


Salivary Gland Mixed Cryoglobulinemia Exocrine Gland Sicca Syndrome Salivary Gland Epithelial Cell 
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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Manuel Ramos-Casals
    • 1
  • Albert Bové
    • 1
  • Rafael Belenguer
    • 2
  • Xavier Forns
    • 3
  • Salvatore de Vita
    • 4
  1. 1.Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Autoimmune DiseasesHospital ClínicBarcelonaSpain
  2. 2.Rheumatology UnitHospital 9 d’OctubreValenciaSpain
  3. 3.Liver Unit, Ciberehd, IDIBAPSHospital ClínicBarcelonaSpain
  4. 4.Rheumatology Clinic, Department of Medical and Biological SciencesAzienda Ospedaliero-Universitaria S Maria della MisericordiaUdineItaly

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