Immunological Tests in Primary Sjögren Syndrome

  • Soledad Retamozo
  • Pilar Brito-Zerón
  • Myriam Gandía
  • Lucio Pallarés
  • Manuel Ramos-Casals


Patients with primary Sjögren syndrome (SS) produce a wide variety of autoantibodies directed at specific nuclear or cytoplasmic antigens. In some cases, the target antigen is present within specific tissues (Table 28.1). B-lymphocyte hyperactivation, the most typical etiopathogenic abnormality of primary SS, accounts for these autoantibodies. Autoantibodies have traditionally been central to classification criteria for SS. The 1993 European Criteria [1] included the presence of one or more of the following four antibodies: antinuclear antibodies (ANA), rheumatoid factor, anti-SSA/Ro, and anti-SSB/La. However, in the 2002 Criteria [2], only anti-SSA/Ro and anti-SSB/La antibodies were included. Together with a positive salivary gland biopsy, the presence of these autoantibodies became mandatory criteria for the classification of primary SS.


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Primary Biliary Cirrhosis Mixed Connective Tissue Disease Articular Involvement 
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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Soledad Retamozo
    • 1
  • Pilar Brito-Zerón
    • 1
  • Myriam Gandía
    • 2
    • 3
  • Lucio Pallarés
    • 4
  • Manuel Ramos-Casals
    • 1
  1. 1.Spanish Group of Autoimmune Diseases (GEAS), Spanish Society of Internal Medicine (SEMI), Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Autoimmune DiseasesICMD Hospital ClínicBarcelonaSpain
  2. 2.Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Autoimmune DiseasesICMD Hospital ClínicBarcelonaSpain
  3. 3.Rheumatology DepartmentHospital Puerta del MarCadizSpain
  4. 4.Autoimmune Diseases UnitHospital Son EspasesPalma de MallorcaSpain

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