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Endocrine Involvement

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Sjögren’s Syndrome

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Abstract

Over the last decades much evidence of communication between the immune, nervous, and endocrine systems has accumulated. This communication has a solid molecular basis. The messengers are hormones, neuropeptides, neurotransmitters, cytokines, and their receptors. These messengers have endocrine action (at a distance), paracrine action (on the neighboring cells), and autocrine action (on the cells themselves). The integrated bidirectional communication of the three systems, now called the immune-neuroendocrine system, regulates the adaptive response to stress [1]. Stressful situations, such as the ones induced by an inflammatory or infectious process, the activation of autoimmunity, trauma, surgery, and emotional events, trigger a series of reactions that activate the immune-neuroendocrine system.

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Authors and Affiliations

  1. Direction of Education and Research, Hospital de Especialidades, Centro Médico La Raza, IMSS, Universidad Nacional Autónoma de México, Mexico City, DF, Mexico

    Luis J. Jara

  2. Clinical and Epidemiology Research Unit, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, DF, Mexico

    Gabriela Medina

  3. Instituto Nacional de Enfermedades Respiratorias, SSA, Mexico City, DF, Mexico

    Carmen Navarro (Deputy Director of Clinical Research)

  4. Department of Internal Medicine, Hospital de Especialidades, Centro Médico Nacional La Raza, IMSS, Universidad Nacional Autónoma de México, Mexico City, DF, Mexico

    Olga Vera-Lastra

  5. Department of Rheumatology, Hospital de Especialidades Centro Médico La Raza, Universidad Nacional Autónoma de México, Mexico City, DF, Mexico

    Miguel A. Saavedra

Authors
  1. Luis J. Jara
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  2. Gabriela Medina
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  3. Carmen Navarro
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  4. Olga Vera-Lastra
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  5. Miguel A. Saavedra
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Editor information

Editors and Affiliations

  1. Barcelona, Surgey, Hospital Clinic, Calle Villarroel, 170, Barcelona, 08036, Spain

    Manuel Ramos-Casals

  2. Massachusetts General Hospital, Boston, 02114, Massachusetts, USA

    John H. Stone

  3. National University of Athens, Athens, Greece

    Haralampos M. Moutsopoulos

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Jara, L.J., Medina, G., Navarro, C., Vera-Lastra, O., Saavedra, M.A. (2011). Endocrine Involvement. In: Ramos-Casals, M., Stone, J., Moutsopoulos, H. (eds) Sjögren’s Syndrome. Springer, London. https://doi.org/10.1007/978-0-85729-947-5_23

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  • DOI: https://doi.org/10.1007/978-0-85729-947-5_23

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