Abstract
Clinicians have long known the severe pulmonary complications that can accompany life-threatening illness or injury. In 1967, Ashbaugh and colleagues described what has now become known as the acute respiratory distress syndrome (ARDS). Their initial description of the syndrome in civilian patients was further appreciated in victims of nonthoracic trauma during the Vietnam War. ARDS has been known by other terms including: Da Nang lung, shock lung, noncardiogenic pulmonary edema and wet lung. ARDS is well described in pediatric patients and therefore “acute respiratory distress syndrome” should be used in place of “adult respiratory distress syndrome”. In 1994, a European-American Consensus Conference formalized a working definition for both acute lung injury and the acute respiratory distress syndrome (Table 24-1). While these definitions are still broadly utilized, many in pediatrics feel that oxygenation index [(mean airway pressure X Fi02) / PaO2] is a more accurate marker of true oxygenation defect.
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Amato MB, Barbas CS, Medeiros DM, et al. Effect of a protective-ventilation strategy on mortality in ARDS. N Engl J Med. 1998; 338:347–54.
Arnold JH, Hanson JH, Toro-Figuero LO, et al. Prospective randomized comparison of HFOV and conventional mechanical ventilation in pediatric respiratory failure. Crit Care Med. 1994;22: 1530–9.
Benjamin M, Tang B, Craig JC, et al. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med. 2009;37:1594–603.
Bernard GR, Artigas A, Brigham KL, et al. The American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149:818–24.
Brower RG, Ware LB, Berthiaume T, Matthay MA. Treatment of ARDS. Chest. 2001;120:1347–67.
Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, et al. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005;294(2):229–37.
Diaz JV, Brower R, Calfee CS, et al. Therapeutic strategies for severe acute lung injury. Crit Care Med. 2010;38:1644–50.
Gattinoni L, Pelosi P, Sutter P, et al. Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease: different syndromes? Am J Respir Crit Care Med. 1998;158:3–11.
Gattinoni L, Caeroni P, Pelosi P, et al. What has computed tomography taught us about acute respiratory distress syndrome? Am J Respir Crit Care Med. 2001;164:1701–11.
Luciano G, Tognoni G, Presenti G, et al. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med. 2001;345:568–73.
Matthews BD, Noviski N. Management of oxygenation in pediatric acute hypoxemic respiratory failure. Pediatr Pulmonol. 2001;32:459–70.
Meduri GU, Headley AS, Golden E, et al. Effect of prolonged methylprednisolone therapy in unresolving ARDS: a randomized controlled trial. JAMA. 1998;280:159–65.
Papazian L, Forel JM, Gacouin A, et al. for the ACURASYS Study Investigators. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363:1107–16.
Priestly M, Helfaer M. Approaches in the management of acute respiratory failure in children. Curr Opin Pediatr. 2004;16:293–8.
Rhoades RA, Tawner GA. Medical physiology. 1st ed. Baltimore: Williams and Wilkins; 1995.
Redding GJ. Current concepts in ARDS in children. Curr Opin Pediatr. 2001;13:261–6.
Sokol J, Jacobs SE, Bohn D. Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults. Cochrane Database Syst Rev. 2003;1:CD002787.
Steinberg K, Hudson L, Goodman R, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med. 2006;354:1671–84.
Timmons OD, Dean JM, Vernon DD. Mortality rates and prognostic variables in children with ARDS. J Pediatr. 1991;119:896–9.
Vaughan DJ, Brogan T. Acute respiratory distress syndrome. eMedicine Journal 2001;2 http://www.emedicine.com/ped/topic50.htm. Accessed 1 May 2011.
Wiedemann HP, Wheeler AP, Bernard GR, et al. for the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564–75.
Willson DF, Thomas NJ, Markovitz BP, Bauman LA, DiCarlo JV, Pon S, et al. Effect of exogenous surfactant (Calfactant) in pediatric acute lung injury: a randomized controlled trial. JAMA. 2005;293:470–6.
Wood LDH, Prewitt RM. Cardiovascular management of hypoxemic respiratory failure. Am J Cardiol. 1981;47:963–72.
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Maffei, F.A., Thomas, N.J. (2012). Acute Respiratory Distress Syndrome. In: Lucking, S., Maffei, F., Tamburro, R., Thomas, N. (eds) Pediatric Critical Care Study Guide. Springer, London. https://doi.org/10.1007/978-0-85729-923-9_24
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DOI: https://doi.org/10.1007/978-0-85729-923-9_24
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