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Use of Blood Products

  • Jill M. Cholette
  • Norma B. Lerner
Chapter

Abstract

Patients in the pediatric intensive care unit (PICU) frequently receive transfusions of blood products. While these therapies are often beneficial, they can be associated with significant, yet often overlooked, risks. Clinical guidelines for blood product transfusions must be well defined in order to prevent misuse of this limited resource. It is important for the intensivist to have a thorough understanding of the indications for specific blood products, and the transfusion needs of particular patient populations.

Keywords

Pediatric Intensive Care Unit Severe Acute Respiratory Syndrome Disseminate Intravascular Coagulation Fresh Freeze Plasma Platelet Transfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Readings

  1. Alderson P, Bunn F, Lefebvre C, et al. The albumin reviewers human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database Syst Rev. 2004;4:CD001208.Google Scholar
  2. Andre M, Vegh P, Johnston M, et al. Maturation of the hemostatic system during childhood. Blood. 1992;80:1998–2005.Google Scholar
  3. AuBuchon JP, editor. Guidelines for blood utilization review. Bethesda: American Association of Blood Banks; 2001.Google Scholar
  4. Bateman ST, Lacroix J, Boven K, et al. Pediatric acute lung injury and sepsis investigators network. Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med. 2008;178:26–33.PubMedCrossRefGoogle Scholar
  5. Blajchman MA. Immunomodulation and blood. Transfusion. 2002;9:389–95.Google Scholar
  6. Bolton-Maggs PHB, Murphy MF. Blood transfusion. Arch Dis Child. 2004;89:4–7.PubMedCrossRefGoogle Scholar
  7. Chiu J, Ketchum LH, Reid TJ. Transfusion-sparing hemostatic agents. Curr Opin Hematol. 2002;9:544–50.PubMedCrossRefGoogle Scholar
  8. Chohann SS, McArdle F, McClelland DBL, et al. Red cell transfusion practice following the transfusion requirements in critical care (TRICC) study: prospective observational cohort study in a large UK intensive care unit. Vox Sang. 2003;84:211–8.CrossRefGoogle Scholar
  9. Cholette JM, Rubenstein JS, Alfieris GM, et al. Children with single ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: Results of a prospective, randomized controlled trial of a restrictive v. liberal transfusion strategy. Pediatr Crit Care Med 2011;12:39–45.CrossRefGoogle Scholar
  10. Corwin HL, Gettinger A, Pearl RG, et al. The CRIT study: anemia and blood transfusion in the critically ill-current clinical practice in the United States. Crit Care Med. 2004;32:39–52.PubMedCrossRefGoogle Scholar
  11. Dzik WH. Leukoreduction of blood components. Curr Opin Hematol. 2002;9:521–6.PubMedCrossRefGoogle Scholar
  12. Fourrier F. Recombinant human activated protein C in the treatment of severe sepsis: an evidence-based review. Crit Care Med. 2004;32:S534–41.PubMedCrossRefGoogle Scholar
  13. Gilstad CW. Anaphylactic transfusion reactions. Curr Opin Hematol. 2003;10:419–23.CrossRefGoogle Scholar
  14. Goodnough LT. Erythropoietin therapy versus red cell transfusion. Curr Opin Hematol. 2001;8:405–10.PubMedCrossRefGoogle Scholar
  15. Goodnough LT. Risks of blood transfusion. Crit Care Med. 2003;31:S678–86.PubMedCrossRefGoogle Scholar
  16. Hebert PC, Schweitzer I, Calder L, et al. Review of the clinical practice literature on allogenic red blood cell transfusion. CMAJ. 1997;156:S9–26.Google Scholar
  17. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med. 1999;340:409–17.PubMedCrossRefGoogle Scholar
  18. Ho J, Sibbald WJ, Chin-Yee IH. Effects of storage on efficacy of red cell transfusion: when is it not safe? Crit Care Med. 2003;31: S687–97.PubMedCrossRefGoogle Scholar
  19. Kiefel V, Konig C, Kroll H, et al. Platelet alloantibodies in transfused patients. Transfusion. 2001;41:766–70.PubMedCrossRefGoogle Scholar
  20. Lacroix J, Tucci M. RBC transfusions in the PICU: The right cutoff? In: Current concepts in pediatric critical care course, Orlando, Florida. 2004. pp. 119–35.Google Scholar
  21. Lacroix J, Hébert PC, Hutchison JS, TRIPICU Investigators; Canadian Critical Care Trials Group; Pediatric Acute Lung Injury and Sepsis Investigators Network, et al. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med. 2007;356:1609–19.PubMedCrossRefGoogle Scholar
  22. Laverdiere C, Gauvin F, Hebert PC, et al. Survey on transfusion practices of pediatric intensivists. Pediatr Crit Care Med. 2002;3:335–40.CrossRefGoogle Scholar
  23. Leal-Noval SR, Jara-Lopez I, Garcia-Garmendia JL, et al. Influence of erythrocyte storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology. 2003;98:815–22.PubMedCrossRefGoogle Scholar
  24. Leavey PJ, Thurman G, Ambruso DR. Functional characteristics of neutrophils collected and stored after administration of G-CSF. Transfusion. 2000;40:414–9.PubMedCrossRefGoogle Scholar
  25. Lemm G. Composition and properties of IVIg preparations that affect tolerability and therapeutic efficacy. Neurology. 2002;59:S28–32.PubMedGoogle Scholar
  26. Liaw PC. Endogenous protein C activation in patients with severe sepsis. Crit Care Med. 2004;32:S214–8.PubMedCrossRefGoogle Scholar
  27. Liles WC, Rodger E, Dale DC. Combined administration of G-CSF and dexamethasone for the mobilization of granulocytes in normal donors: optimization of dosing. Transfusion. 2000;40:642–4.PubMedCrossRefGoogle Scholar
  28. Luban NLC. Basics of transfusion medicine. In: Fuhrman BP, Zimmerman JJ, editors. Pediatric critical care. 3rd ed. Philadelphia: Mosby; 2006. p. 1185–98.CrossRefGoogle Scholar
  29. Marik PE, Sibbald WJ. Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA. 1993;269:3024–9.PubMedCrossRefGoogle Scholar
  30. Morris KP, Naqvi N, Davies P, Smith M, Lee PW. A new formula for blood transfusion volume in the critically ill. Arch Dis Child. 2005;90:724–8.PubMedCrossRefGoogle Scholar
  31. Nevo S, Vogelsang GB. Acute bleeding complications in patients after bone marrow transplantation. Curr Opin Hematol. 2001;8:319–25.PubMedCrossRefGoogle Scholar
  32. Nichols WG, Price TH, Gooley T, et al. Transfusion-transmitted cytomegalovirus infection after receipt of leukoreduced blood products. Blood. 2003;101:4195–200.PubMedCrossRefGoogle Scholar
  33. Nowak-Wegrzyn A, Lederman HM. Supply, use, and abuse of intravenous immunoglobulin. Curr Opin Pediatr. 1999;11:533–9.PubMedCrossRefGoogle Scholar
  34. Pomper GJ, Wu Y, Snyder EL. Risks of transfusion-transmitted infections. Curr Opin Hematol. 2003;10:412–8.PubMedCrossRefGoogle Scholar
  35. Roseff SD, Luban NLC, Manno CS. Guidelines for assessing appropriateness of pediatric transfusion. Transfusion. 2002;42:1398–413.PubMedCrossRefGoogle Scholar
  36. Sanchez R, Toy P. Transfusion related acute lung injury: a pediatric perspective. Pediatr Blood Cancer. 2005;45:248–55.PubMedCrossRefGoogle Scholar
  37. Schiffer CA, Anderson KC, Bennett CL, et al. Platelet transfusion for patients with cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19:1519–38.PubMedGoogle Scholar
  38. Silliman CC, Ambruso DR, Boshkov LK. Transfusion-related acute lung injury. Blood. 2005;105:2266–73.PubMedCrossRefGoogle Scholar
  39. The SAFE study investigators. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350:2247–56.CrossRefGoogle Scholar
  40. Tinmouth A, Chin-Yee I. The clinical consequences of the red cell storage lesion. Transfus Med Rev. 2001;15:91–107.PubMedCrossRefGoogle Scholar
  41. Triulzi DJ. Specialized transfusion support for solid organ transplantation. Curr Opin Hematol. 2002;9:527–32.PubMedCrossRefGoogle Scholar
  42. Vincent JL, Baron JF, Reinhart K, et al. Anemia and blood transfusion in critically Ill patients. JAMA. 2002;288:1499–507.PubMedCrossRefGoogle Scholar
  43. Werdan K. Intravenous immunoglobulin for prophylaxis and therapy of sepsis. Curr Opin Crit Care. 2001;7:354–61.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  1. 1.Pediatric Critical Care Medicine, Department of PediatricsUniversity of Rochester School of Medicine and Dentistry, Golisano Children’s HospitalRochesterUSA
  2. 2.Pediatric Hematology, Department of PediatricsDrexel University College of Medicine, St. Christopher’s Hospital for ChildrenPhiladelphiaUSA

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