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The Therapeutic Potential of Dimethylarginine Dimethylaminohydrolase–Mediated Regulation of Nitric Oxide Synthesis

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Translational Vascular Medicine

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Abstract

The establishment and progression of cardiovascular disease is associated with endothelial dysfunction. It is widely accepted that nitric oxide production from the vascular endothelium plays a key role in regulation of vascular function in normal health and during disease. Therefore, mechanisms that regulate vascular nitric oxide production have become the focus of significant attention from both vascular biologists and the pharmaceutical industry. The inhibition of nitric oxide synthase activity by endogenously produced competitive inhibitors has recently been linked to reduced nitric oxide synthesis in numerous animal models of disease and several human disease states. In this chapter, we will review the current literature describing these relationships and briefly focus on the pharmacological effects that some of the current therapies for treating these diseases might have on this pathway.

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Authors and Affiliations

  1. MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, UK

    James Leiper

  2. School of Pharmacy and Chemistry, Kingston University, Kingston-Upon-Thames, Surrey, UK

    Francesca Arrigoni & Bierina Ahmetaj

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  2. The Royal Free & Univ College Med School, Gower Street, London, WC1E 6BT, United Kingdom

    Clive Handler

  3. University College London, Gower Street, London, WC1E 6BT, United Kingdom

    Michael Dashwood

  4. The Royal Free & Univ College Med School, Gower Street, London, WC1E 6BT, United Kingdom

    Gerry Coghlan

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© 2012 Springer-Verlag London Limited

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Leiper, J., Arrigoni, F., Ahmetaj, B. (2012). The Therapeutic Potential of Dimethylarginine Dimethylaminohydrolase–Mediated Regulation of Nitric Oxide Synthesis. In: Abraham, D., Handler, C., Dashwood, M., Coghlan, G. (eds) Translational Vascular Medicine. Springer, London. https://doi.org/10.1007/978-0-85729-920-8_5

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  • DOI: https://doi.org/10.1007/978-0-85729-920-8_5

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