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How Should Gynecological Sarcomas Be Managed?

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Controversies in the Management of Gynecological Cancers

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Abstract

Uterine sarcomas are malignant tumors of mesenchymal origin. They are rare, accounting for 8 % of all uterine tumors and 7 % of all soft tissue sarcomas. Uterine sarcomas are classified into uterine leiomyosarcomas, adenosarcomas, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. Uterine carcinosarcomas have historically been classified as uterine sarcomas but more recently have been recognized as a subtype of endometrial carcinoma, and so are not discussed here. For each uterine sarcoma subtype, we discuss epidemiology and diagnosis, histopathology, and management of early and advanced/metastatic disease with surgery, radiotherapy, and systemic therapy, discussing standard treatment and areas of controversy.

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Authors and Affiliations

  1. Department of Oncology, University College Hospital, 1st Floor Central, 250 Euston Road, London, NW1 2PG, UK

    Beatrice Seddon MBBS, MRCP, FRCR, PhD

  2. Department of Gynaecological Oncology, University Hospitals, Leuven-Campus Gasthuisberg, Herestraat 49, Leuven, 3000, Belgium

    Frederic Amant MD, PhD

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  1. Beatrice Seddon MBBS, MRCP, FRCR, PhD
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  2. Frederic Amant MD, PhD
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Correspondence to Beatrice Seddon MBBS, MRCP, FRCR, PhD .

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Editors and Affiliations

  1. UCL Cancer Institute, University College London, London, United Kingdom

    Jonathan A. Ledermann

  2. Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands

    Carien L. Creutzberg

  3. Royal Women’s Hospital, The University of Melbourne, Melbourne, Australia

    Michael A. Quinn

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Seddon, B., Amant, F. (2014). How Should Gynecological Sarcomas Be Managed?. In: Ledermann, J., Creutzberg, C., Quinn, M. (eds) Controversies in the Management of Gynecological Cancers. Springer, London. https://doi.org/10.1007/978-0-85729-910-9_28

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  • DOI: https://doi.org/10.1007/978-0-85729-910-9_28

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