Do Intensity-Modulated Radiation, Image-Guided Radiation, and 3D Brachytherapy Significantly Advance Radiotherapeutic Management of Gynecologic Cancers?

  • Akila Ninette Viswanathan
  • Jacob Christian Lindegaard


The use of 3-dimensional (3D) imaging to enhance radiation delivery for gynecologic malignancies has increased dramatically in the past decade. Advances in technology have permitted a rapid evolution in the fields of intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), and 3D image-planned brachytherapy (3DBT). In cervical and endometrial cancer, significant progress has been made in the implementation of postoperative IMRT. The use of IMRT and IGRT in the setting of locally advanced gynecologic cancer remains controversial due to issues surrounding organ and tumor changes during the course of treatment. Advantages of and controversies over the use of IMRT, IGRT, and 3DBT will be discussed in detail. Specifically, the role of proper target delineation and the importance of accurate contouring, the problem of organ motion and tumor tracking, and an overview of clinical outcomes will be presented. The use of these new technologies remains in its early development, with the potential for substantial progress in the future.


Cervical Cancer Planning Target Volume Clinical Target Volume Radiation Therapy Oncology Group Cervical Cancer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Akila Ninette Viswanathan
    • 1
  • Jacob Christian Lindegaard
    • 2
  1. 1.Department of Radiation OncologyRadiation Oncology Brigham and Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical SchoolBostonUSA
  2. 2.Department of OncologyAarhus University HospitalAarhusDenmark

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