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Maintenance Therapy for First-Line Treatment of Ovarian Cancer: Is This the Strategy for the Future?

  • Nicoletta Colombo
  • Lucas Minig
  • Robert Burger
Chapter

Abstract

The majority of women with epithelial ovarian cancer are diagnosed an advanced stage of disease. Over 70 % of them will experience a relapse of the disease in a mean time of 15 month; only 30–40 % will survive 5 years. Several treatment strategies have been evaluated for prolonging the time free of disease and reducing the risk of death. Maintenance treatment, i.e., continuation of primary chemotherapy in patients without progression of the disease, has been studied with a variety of agents ranging from purely cytotoxic drugs to targeted molecules such as bevacizumab. However, several controversies regarding the impact of maintenance therapy for treating women with ovarian cancer exist. This chapter details the advantages and disadvantages of continuation medical treatment in newly diagnosed ovarian cancer after primary treatment based on the highest levels of evidence.

Keywords

Ovarian Cancer Maintenance Therapy Epithelial Ovarian Cancer Advanced Ovarian Cancer Recurrent Ovarian Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Gynecology OncologyEuropean Institute of OncologyMilanItaly
  2. 2.Gynecology OncologyCentro Integral Oncológico Clara Campal (CIOCC)MadridSpain
  3. 3.Department of Surgical OncologyFox Chase Cancer CenterPhiladelphiaUSA

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