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What Are the Treatment Options for Recurrent Ovarian Cancer?

  • Jonathan A. Ledermann
  • Fharat A. Raja
  • Philipp Harter
  • Florian Heitz
Chapter

Abstract

Most women with advanced ovarian cancer will suffer a recurrence. There are many therapeutic options to consider at relapse, and it is the careful selection and use of chemotherapy and sometimes surgery that has over the last decade extended survival. Debulking surgery at relapse is currently undertaken with careful patient selection, but ongoing randomized trials will identify whether this approach is worthwhile and which patient will benefit. There are now many options for patients with “platinum-sensitive” recurrence, and combination therapy has been shown to be superior to single-agent platinum therapy. The term “platinum resistance” needs careful consideration, and treatment decisions for “platinum-resistant” disease are more difficult due to the heterogeneity of the condition. Molecular targeted therapy directed against angiogenesis, inherited and acquired defects of DNA repair, and intracellular signaling pathways are showing promise. Antiangiogenic agents and PARP inhibitors are the leading classes of compounds targeting molecular pathways. The incorporation of these and other agents will require carefully designed and conducted clinical studies to establish their place in the treatment pathway.

Keywords

Ovarian Cancer Epidermal Growth Factor Receptor Cytoreductive Surgery PARP Inhibitor Epidermal Growth Factor Receptor Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Jonathan A. Ledermann
    • 1
  • Fharat A. Raja
    • 1
  • Philipp Harter
    • 2
  • Florian Heitz
    • 3
  1. 1.UCL Cancer InstituteUniversity College London, Cancer Research UK and UCL Cancer Trials CentreLondonUK
  2. 2.Department of Gynecology and Gynecological OncologyKliniken Essen MitteEssenGermany
  3. 3.Gynecology and Gynecologic OncologyKliniken Essen-Mitte/Evangel HuyssensstiftungEssenGermany

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