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Pruritus Ani

  • Ian Badger
Chapter

Abstract

Itch is the sensation that provokes an urge to scratch, which distinguishes it from pain (which induces a withdrawal response). The physiology of itch is imperfectly understood. Itch receptors are apparently unspecialized nerve endings in the skin and cornea that lead to unmyelinated C fibers that travel in the spinothalamic tracts. Both histamine and interleukin-1 are mediators of itch; prostaglandin E1 lowers the itch sensory threshold; and substance P can cause itching by inducing the release of histamine. Endogenous opioids and exogenous opiates can cause itching.

Keywords

Methylene Blue Rectal Prolapse Perianal Skin Barrier Cream Fungal Skin Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  1. 1.Department of General SurgeryRoyal Wolverhampton Hospital Trust, New Cross HospitalWolverhamptonUK

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